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JAK2 and SOCS1
Number of citations of the paper that reports this interaction (PubMedID
11971965
)
58
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
JAK2
SOCS1
Description
Janus kinase 2
suppressor of cytokine signaling 1
Image
No pdb structure
GO Annotations
Cellular Component
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Caveola
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Endosome Lumen
Interleukin-12 Receptor Complex
Membrane Raft
Interleukin-23 Receptor Complex
Postsynapse
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Vesicle
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Growth Hormone Receptor Binding
Interleukin-12 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heme Binding
Signaling Receptor Activator Activity
Type 1 Angiotensin Receptor Binding
Acetylcholine Receptor Binding
Histone H3Y41 Kinase Activity
SH2 Domain Binding
Histone Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Peptide Hormone Receptor Binding
Protein Kinase Inhibitor Activity
Cytokine Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Kinase Inhibitor Activity
Protein Kinase Binding
Biological Process
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Apoptotic Process
Immune Response
Response To Oxidative Stress
Cell Adhesion
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Hormone-mediated Signaling Pathway
Positive Regulation Of Platelet Activation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cell-substrate Adhesion
Cytokine-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell-cell Adhesion
Actin Filament Polymerization
Myeloid Cell Differentiation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Axon Regeneration
Lipopolysaccharide-mediated Signaling Pathway
Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Proliferation
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Symbiont-induced Defense-related Programmed Cell Death
Response To Tumor Necrosis Factor
Post-embryonic Hemopoiesis
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Cellular Response To Interleukin-3
Interleukin-5-mediated Signaling Pathway
Collagen-activated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Post-translational Protein Modification
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Response To Antibiotic
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Inflammatory Response
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cell Activation
Positive Regulation Of NK T Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Type II Interferon-mediated Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Epithelium Development
Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Leukocyte Proliferation
Response To Interleukin-12
Interleukin-35-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Dexamethasone Stimulus
Extrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cold-induced Thermogenesis
Defense Response To Symbiont
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Cytokine Production
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Macrophage Differentiation
Developmental Process
Intracellular Signal Transduction
Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Fat Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Cellular Response To Amino Acid Stimulus
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Signaling by Erythropoietin
Signaling by Erythropoietin
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
IFNG signaling activates MAPKs
Growth hormone receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
Interleukin-7 signaling
Regulation of KIT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
XL019
5-phenyl-1H-indazol-3-amine
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
Ruxolitinib
Tofacitinib
Pacritinib
Baricitinib
Entrectinib
Fostamatinib
Fedratinib
Abrocitinib
Zanubrutinib
Pralsetinib
Diseases
Polycythemia vera
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
23266558
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Eosinophilic esophagitis (
34506852
)
HDL cholesterol (
30275531
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol (
30275531
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
19287384
25849990
33057200
)
Neutrophil count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
24777453
32888494
27863252
28031487
)
Plateletcrit (
27863252
32888494
)
Psoriatic arthritis (
26626624
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
19915573
20228799
21297633
26398853
)
White blood cell count (
32888494
)
Allergy (
27182965
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
29273806
)
Bulimia nervosa (
23568457
)
Celiac disease (
20190752
)
Crohn's disease (
28067908
)
Crohn's disease and psoriasis (
22482804
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Inflammatory bowel disease (
23128233
28067908
)
Multiple sclerosis (
31604244
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Psoriasis (
23143594
)
Psoriasis vulgaris (
26626624
)
Systemic lupus erythematosus (
27399966
26502338
)
Interacting Genes
99 interacting genes:
ABL1
AGTR1
ARL11
ASS1
BCR
BRCA1
CBL
CCR5
CISH
CRLF2
CSF2RB
CSF3R
CTLA4
CXCR4
DNAJA3
EGFR
ELP2
EPOR
ERBB2
ERBB3
EZH2
FES
FYN
GHR
GRB10
GRB2
GTF2I
H3-4
HES1
HES5
HSFY1
HSPA8
HTR2A
IFNGR1
IFNGR2
IGF1R
IKBKG
IL12RB2
IL23R
IL3RA
IL4R
IL5RA
INSR
IRS1
IRS2
JAK1
JAK3
KIT
LEPR
LYN
MAP3K5
MDK
MPL
MST1R
NFKBIA
OSMR
PDGFRB
PIK3R1
PKD1
PLCG2
PPIA
PPP1CC
PPP2CA
PPP2R1B
PPP2R5A
PRLR
PRMT5
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN6
PTPRC
RAF1
RBMX
SH2B1
SH2B2
SHC1
SIRPA
SOCS1
SOCS3
STAM
STAM2
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
TEC
TNFRSF1A
TRAF6
TSHR
TUB
UBASH3B
VAV1
VCP
YES1
54 interacting genes:
AXL
BLK
COMMD1
CRK
CSF1
CSF1R
CUEDC2
CXCR4
CYTIP
EGFR
ELOB
ELOC
ERBB2
ERBB4
FLT3
FYN
GHR
GRB2
IFNAR1
IFNGR1
IGF1R
IL2RB
INSR
IRF7
IRS1
IRS2
ITK
JAK1
JAK2
JAK3
KIT
LCK
LYN
MET
MIR924HG
MPL
NCK1
PDGFRB
PIK3R1
PIK3R2
PIM2
PTK2
RELA
SH3GL1
SRC
TEC
TEK
TIRAP
TP53
TRIM8
TYK2
VAV1
VAV2
YES1
Entrez ID
3717
8651
HPRD ID
00993
04669
Ensembl ID
ENSG00000096968
ENSG00000185338
Uniprot IDs
A8K910
B4DYV1
O60674
O15524
Q4JHT5
PDB IDs
2B7A
2W1I
2XA4
3E62
3E63
3E64
3FUP
3IO7
3IOK
3JY9
3KCK
3KRR
3LPB
3Q32
3RVG
3TJC
3TJD
3UGC
3ZMM
4AQC
4BBE
4BBF
4C61
4C62
4D0W
4D0X
4D1S
4E4M
4E6D
4E6Q
4F08
4F09
4FVP
4FVQ
4FVR
4GFM
4GMY
4HGE
4IVA
4JI9
4JIA
4P7E
4YTC
4YTF
4YTH
4YTI
4Z32
4ZIM
5AEP
5CF4
5CF5
5CF6
5CF8
5HEZ
5I4N
5L3A
5TQ3
5TQ4
5TQ5
5TQ6
5TQ7
5TQ8
5USY
5USZ
5UT0
5UT1
5UT2
5UT3
5UT4
5UT5
5UT6
5WEV
5WIJ
5WIK
5WIL
5WIM
5WIN
6AAJ
6BBV
6BRW
6BS0
6BSS
6D2I
6DRW
6E2P
6E2Q
6G3C
6M9H
6OAV
6OBB
6OBF
6OBL
6OCC
6TPD
6VGL
6VN8
6VNB
6VNC
6VNE
6VNF
6VNG
6VNH
6VNI
6VNJ
6VNK
6VNL
6VNM
6VS3
6VSN
6WTN
6WTO
6WTP
6WTQ
6X8E
6XJK
7F7W
7JYO
7JYQ
7LL4
7LL5
7Q7I
7Q7K
7Q7L
7Q7W
7REE
7RN6
7SZW
7T0P
7T1T
7TEU
7UYW
8B8N
8B8U
8B99
8B9E
8B9H
8BA2
8BA3
8BA4
8BAB
8BAK
8BM2
8BPV
8BPW
8BX6
8BX9
8BXC
8BXH
8C08
8C09
8C0A
8CZ9
8EX0
8EX1
8EX2
8EXK
8EYA
8EYB
8F88
8G6Z
8G8O
8G8X
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine Receptor Activity
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway Via STAT
Receptor Complex
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Protein Tyrosine Kinase Activity
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Cytokine Binding
Regulation Of Cell Differentiation
Regulation Of Developmental Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell-cell Adhesion
Positive Regulation Of Metabolic Process
Positive Regulation Of Immune System Process
Regulation Of Cell Activation
Cell Activation
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Regulation Of Cell Development
Positive Regulation Of Lymphocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Phosphotyrosine Residue Binding
Positive Regulation Of Cell Activation
Growth Hormone Receptor Signaling Pathway
Leukocyte Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Hemopoiesis
Regulation Of MAPK Cascade
Regulation Of Programmed Cell Death
Response To Cytokine
Regulation Of T Cell Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Peptidyl-tyrosine Phosphorylation
Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune System Process
Protein Phosphorylation
Cytokine-mediated Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Activity
Phosphorylation
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Immune System Process
Protein Phosphatase Binding
Regulation Of Immune System Process
Phosphatidylinositol 3-kinase Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Positive Regulation Of MAPK Cascade
Protein Autophosphorylation
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Growth Hormone Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
ATP Binding
Immune Response-activating Signaling Pathway
Positive Regulation Of Metabolic Process
Phosphotyrosine Residue Binding
Regulation Of Immune Response
Plasma Membrane
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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