EED and PJA1

Number of citations of the paper that reports this interaction (PMID 21513699)
7

Data Source:
BioGRID (enzymatic study)

		EED	PJA1
Gene Name		embryonic ectoderm development	praja ring finger 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus	Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation	Protein Ubiquitination Protein Catabolic Process
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	36 interactors: ASCC2 ATP5C1 ATXN3 ATXN3L EED ESPL1 EZH2 GSR HNRNPL JOSD1 KIF22 MAGED1 MDM2 NDN NDNL2 OTUB1 OTUB2 RIBC2 SPTBN1 STAM STAMBP SUZ12 UBC UBE2D2 UBE2D3 UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP7 USP8 ZNF440
Entrez ID		8726	64219
HPRD ID		09343	02335
Ensembl ID		ENSG00000074266	ENSG00000181191
Uniprot IDs		E9PJK2 O75530	Q8NG27
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27	2L0B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process	Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Catabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process DNA Repair Cellular Response To Stress Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Proteolysis Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Cell Cycle Process Metabolic Process Nitrogen Compound Metabolic Process Protein Polyubiquitination Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromosome Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Ubiquitination Cell Cycle Cytokinesis Protein Modification By Small Protein Conjugation Chromatin Modification Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?