EED and ZFP42

Number of citations of the paper that reports this interaction (PMID 21530438)
7

Data Source:
BioGRID (two hybrid)

		EED	ZFP42
Gene Name		embryonic ectoderm development	ZFP42 zinc finger protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleus Cytoplasm Protein Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation	In Utero Embryonic Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Meiotic Nuclear Division Spermatid Development Male Gonad Development Female Gonad Development Regulation Of Genetic Imprinting
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	3 interactors: EED RYBP YAF2
Entrez ID		8726	132625
HPRD ID		09343	15726
Ensembl ID		ENSG00000074266	ENSG00000179059
Uniprot IDs		E9PJK2 O75530	Q96MM3
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone Modification Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Histone H2A Monoubiquitination Regulation Of Histone H3-K27 Methylation Histone H2A Ubiquitination Chromatin Modification RNA Metabolic Process Histone Monoubiquitination Chromatin Organization Gene Expression Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Genetic Imprinting Histone Ubiquitination Positive Regulation Of Histone Methylation Protein Monoubiquitination Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone Modification Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Histone Methylation Regulation Of Histone Modification Protein Methylation Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	adipogenic adipose ascs cdk2 chip deteriorated esc escs express fate hairpin hbm hmscs hucb inversely knockdown knocked lentiviral mapk mkk3 mscs osteogenic p38 recovered restored rex rex1 shrna umbilical
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	adipogenic adipose ascs cdk2 chip deteriorated escs express fate hairpin hbm hmscs hucb inversely knockdown knocked lentiviral mapk mkk3 mscs osteogenic p38 recovered restored rex rex1 shrna umbilical
Tagcloud (Intersection) ?		esc