EED and ZFP42

Number of citations of the paper that reports this interaction (PubMedID 21530438)
0

Data Source:
BioGRID (two hybrid)

		EED	ZFP42
Description		embryonic ectoderm development	ZFP42 zinc finger protein
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus	Chromatin Nucleus Transcription Regulator Complex Cytoplasm PcG Protein Complex
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Regulation Of Transcription By RNA Polymerase II Male Gonad Development Female Gonad Development Meiotic Cell Cycle
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Cortisol levels (saliva) ( 28843169) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Testicular germ cell tumor ( 28604728 28604732) Visceral fat ( 30942860)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42	8 interacting genes: EED LHX2 MEOX2 PIAS2 RNF4 RYBP SUMO1 YAF2
Entrez ID		8726	132625
HPRD ID		09343	15726
Ensembl ID		ENSG00000074266	ENSG00000179059
Uniprot IDs		E9PJK2 O75530	Q96MM3
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II PML Body Transcription Coregulator Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process Nucleosome Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Roof Of Mouth Development Positive Regulation Of Macromolecule Metabolic Process Nuclear Speck Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Adaxial/abaxial Pattern Formation Positive Regulation Of Metabolic Process Regulation Of Kinetochore Assembly Protein Localization To Nuclear Pore Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Somite Specification SUMO Polymer Binding Negative Regulation Of Action Potential Small Protein Activating Enzyme Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Centromere Complex Assembly Nucleoplasm Negative Regulation Of Protein Localization To Chromatin Microtubule End Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Telencephalon Regionalization
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