EED and SELENBP1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EED	SELENBP1
Gene Name		embryonic ectoderm development	selenium binding protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus	Extracellular Space Nucleolus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding	Protein Binding Selenium Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation	Protein Transport
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	12 interactors: BARD1 EED GORASP2 GPX1 LRIF1 MED31 MLH1 POLDIP2 RPA1 TRA2A TRIP13 USP33
Entrez ID		8726	8991
HPRD ID		09343	05007
Ensembl ID		ENSG00000074266	ENSG00000143416
Uniprot IDs		E9PJK2 O75530	A6PVW9 Q13228
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process See more	Cell Cycle Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Meiotic Nuclear Division Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Meiotic Cell Cycle DNA Repair DNA Recombination Multicellular Organismal Homeostasis Nitrogen Compound Metabolic Process Reciprocal Meiotic Recombination Organelle Organization Synapsis Mismatch Repair Homologous Chromosome Segregation Male Meiosis Meiotic Spindle Midzone Assembly Positive Regulation Of Fibril Organization Meiotic Metaphase I Plate Congression Cellular Response To DNA Damage Stimulus Oogenesis Meiotic Chromosome Segregation Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Recombination Negative Regulation Of MRNA 3'-end Processing Response To Symbiotic Bacterium Chromosome Organization Meiosis I Aromatic Compound Catabolic Process Female Gamete Generation DNA Metabolic Process Regulation Of Fibril Organization Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Response To Lipid Hydroperoxide DNA Recombinase Assembly RNA Metabolic Process Myoblast Proliferation Negative Regulation Of Protein Export From Nucleus Protein Oxidation Response To Selenium Ion Tissue Homeostasis Response To Stress Gene Expression Protein K6-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway See more
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	aci arthritis ccl2 chemicals cia10 cia25 cia3d cia5a cigarette clec4m congenic congenics core correlating da erosive f344 mediators nonerosive nongenetic nongenetically rheumatoid scd1 slc7a10 spond1 synovial tnn upstream xenobiotic
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	aci arthritis ccl2 chemicals cia10 cia25 cia3d cia5a cigarette clec4m congenic congenics core correlating da erosive f344 mediators nonerosive nongenetic nongenetically rheumatoid scd1 slc7a10 spond1 synovial tnn upstream xenobiotic
Tagcloud (Intersection) ?