EED and NUDT21

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		EED	NUDT21
Description		embryonic ectoderm development	nudix hydrolase 21
Image
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Cytoplasm Centrosome MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Nuclear Body Centriolar Satellite Paraspeckles
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	MRNA Processing Post-transcriptional Regulation Of Gene Expression Cell Differentiation MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Pro-B Cell Differentiation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42	119 interacting genes: A2M ATXN1 CARM1 CDC42 CEBPA CEP126 CLP1 CPSF6 CPSF7 CTNND2 DBN1 DNMT3L DYNC1I1 EED EEF1G ESR1 EXOSC6 F13A1 FAM90A1 FBN3 FLAD1 FUNDC2 GOLGA2 HSF4 IKZF1 ITCH JMJD1C KIFAP3 KRT75 MASP1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-2 MIR138-1 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200B MIR205 MIR206 MIR20A MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-2 MIR9-2 MIR92A1 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYL6 NEDD4 NGEF NIF3L1 NTAQ1 POLR2C PSMF1 PSPC1 PTN PYCR1 RBM48 RCC1 RNF19A RPLP1 S100PBP SEM1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP SNRNP70 SPAG8 SRPK1 TCERG1 TEPSIN TLE1 TRA2A TRIM23 TRIM27 WWOX ZNF655
Entrez ID		8726	11051
HPRD ID		09343	05400
Ensembl ID		ENSG00000074266	ENSG00000167005
Uniprot IDs		E9PJK2 O75530	O43809
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	2CL3 2J8Q 3BAP 3BHO 3MDG 3MDI 3N9U 3P5T 3P6Y 3Q2S 3Q2T 5R4P 5R4Q 5R4R 5R4S 5R4T 5R4U 5R64 5R65 5R66 5R67
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process	MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Blood Vessel Endothelial Cell Migration MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of Developmental Process Negative Regulation Of Sprouting Angiogenesis Regulation Of Metabolic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Translation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Sprouting Angiogenesis Negative Regulation Of Protein Metabolic Process
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