EED and EHMT1

Number of citations of the paper that reports this interaction (PubMedID 24457600)
57

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		EED	EHMT1
Description		embryonic ectoderm development	euchromatic histone lysine methyltransferase 1
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GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding	Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Response To Fungicide Positive Regulation Of Cold-induced Thermogenesis Facultative Heterochromatin Formation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases			Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42	13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ
Entrez ID		8726	79813
HPRD ID		09343	07383
Ensembl ID		ENSG00000074266	ENSG00000181090
Uniprot IDs		E9PJK2 O75530	A0A1B0GUD1 A0A1B0GV09 Q9H9B1
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP 7T7M 8XPT
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process	Epigenetic Regulation Of Gene Expression Nucleoplasm Chromatin Remodeling Transcription Corepressor Binding Pronucleus Chromatin Binding Chromatin Organization Cellular Response To Antibiotic Chromatin Silencing Complex Nucleus ESC/E(Z) Complex Regulation Of Gliogenesis Facultative Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulatory NcRNA-mediated Heterochromatin Formation Genomic Imprinting Nuclear Matrix Heterochromatin Formation Regulation Of RNA Metabolic Process LncRNA Binding Negative Regulation Of Gene Expression, Epigenetic Epigenetic Programming Of Gene Expression Regulation Of Gene Expression Nucleosome Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Antibiotic Regulation Of Glial Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Hepatocyte Homeostasis Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein-cysteine Methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Promoter-specific Chromatin Binding Cellular Response To Trichostatin A Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle DNA Replication, Okazaki Fragment Processing 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity
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