EED and EPC2

Number of citations of the paper that reports this interaction (PMID 22659877)
26

Data Source:
BioGRID (unspecified method)

		EED	EPC2
Gene Name		embryonic ectoderm development	enhancer of polycomb homolog 2 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus	Piccolo NuA4 Histone Acetyltransferase Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 21123754) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42	2 interactors: EED EZH2
Entrez ID		8726	26122
HPRD ID		09343	13274
Ensembl ID		ENSG00000074266	ENSG00000135999
Uniprot IDs		E9PJK2 O75530	Q52LR7
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process	Negative Regulation Of Gene Expression, Epigenetic Histone Methylation Protein Methylation Regulation Of Gene Expression, Epigenetic Histone Modification Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Methylation Chromatin Modification G1 To G0 Transition Negative Regulation Of Epidermal Cell Differentiation Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation Chromatin Organization Protein Localization To Chromatin Regulation Of Histone H3-K27 Methylation Positive Regulation Of Protein Modification Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Striated Muscle Cell Differentiation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Skeletal Muscle Tissue Regeneration Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation Regulation Of Retinoic Acid Receptor Signaling Pathway Tissue Regeneration Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Cellular Response To Hydrogen Peroxide DNA Methylation Cerebellar Cortex Development Regulation Of Epidermis Development Positive Regulation Of Histone Modification Regulation Of Cellular Component Organization
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	affymetrix altering barrett caudal cdx2 columnar emerges engineered epithelium gained homeobox htert immortalized intestinalization intestinalized intestine keratinocytes oesophageal oesophagus provoke remodelling rescued resemblance retroviral similarities transcriptase transiently unanswered unexpectedly
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	affymetrix altering barrett caudal cdx2 columnar emerges engineered epithelium gained homeobox htert immortalized intestinalization intestinalized intestine keratinocytes oesophageal oesophagus provoke remodelling rescued resemblance retroviral similarities transcriptase transiently unanswered unexpectedly
Tagcloud (Intersection) ?