EED and EPC2

Number of citations of the paper that reports this interaction (PubMedID 22659877)
0

Data Source:
BioGRID (unspecified method)

		EED	EPC2
Description		embryonic ectoderm development	enhancer of polycomb 2
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus	Nucleosome Nucleus Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Alzheimer's disease biomarkers ( 21123754) Chronotype ( 30696823) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Relative amplitude of rest-activity cycles ( 30120083) Schizophrenia ( 29483656 30285260) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42	2 interacting genes: EED EZH2
Entrez ID		8726	26122
HPRD ID		09343	13274
Ensembl ID		ENSG00000074266	ENSG00000135999
Uniprot IDs		E9PJK2 O75530	Q52LR7
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process	Pronucleus ESC/E(Z) Complex Facultative Heterochromatin Formation Chromatin Silencing Complex Nucleosome Binding Transcription Corepressor Binding Hepatocyte Homeostasis Peptidase Complex Cellular Response To Trichostatin A Melanocyte Apoptotic Process Regulation Of Adaxial/abaxial Pattern Formation Heterochromatin Formation Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Melanocyte Proliferation Regulation Of Collagen Catabolic Process Negative Regulation Of Interferon-alpha Production Histone H3K27 Methyltransferase Activity Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cerebellar Cortex Development Sex Chromatin Primary MiRNA Binding Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Keratinocyte Differentiation Cobalamin Metabolic Process Cellular Response To Antibiotic Subtelomeric Heterochromatin Formation Negative Regulation Of Extracellular Matrix Disassembly Molecular Carrier Activity Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cytokine Production Negative Regulation Of Epidermal Cell Differentiation Dipeptidyl-peptidase Activity G1 To G0 Transition Positive Regulation Of Dendrite Development Negative Regulation Of Interferon-beta Production Positive Regulation Of Protein Modification Process Basal Part Of Cell Regulation Of Fibrinolysis Positive Regulation Of Protein Polyubiquitination
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