EED and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 22094255)
39

Data Source:
BioGRID (imaging technique, affinity chromatography technology)
HPRD (in vitro)

		EED	DNMT3B
Description		embryonic ectoderm development	DNA methyltransferase 3 beta
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GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Cytosol ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Catalytic Complex
	Molecular Function	Transcription Corepressor Binding Chromatin Binding Protein Binding Enzyme Activator Activity Nucleosome Binding Identical Protein Binding	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Spinal Cord Development Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Oligodendrocyte Differentiation Genomic Imprinting Facultative Heterochromatin Formation Cellular Response To Leukemia Inhibitory Factor Regulation Of Adaxial/abaxial Pattern Formation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Decitabine
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FAM200C FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZFP42	39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		8726	1789
HPRD ID		09343	04209
Ensembl ID		ENSG00000074266	ENSG00000088305
Uniprot IDs		E9PJK2 O75530	A0A8Q3SIG2 Q9UBC3
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6LO2 6SFB 6SFC 6U4Y 6V3X 6V3Y 6W7F 6W7G 6WKR 6YVI 6YVJ 7KSO 7KSR 7KTP 7KXT 7MSB 7MSD 7P3C 7P3G 7P3J 7QJG 7QJU 7QK4 7SI4 7SI5 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Formation Epigenetic Regulation Of Gene Expression Methyltransferase Activity Nucleus Methylation Constitutive Heterochromatin Formation Nucleoplasm DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K27 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Transcription By RNA Polymerase II Histone Methyltransferase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein De-2-hydroxyisobutyrylase Activity Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Transcription Corepressor Binding Transferase Activity Heterochromatin NuRD Complex Transcription Corepressor Activity Negative Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding DNA-methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Fungiform Papilla Formation Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process	Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation
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