CBL and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		CBL	TRAF4
Description		Cbl proto-oncogene	TNF receptor associated factor 4
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Membrane Flotillin Complex Axon Growth Cone Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Membrane Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cadherin Binding Metal Ion Binding Ephrin Receptor Binding Ubiquitin Protein Ligase Activity Protein Tyrosine Kinase Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding WW Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Signal Transduction Cell Surface Receptor Signaling Pathway Male Gonad Development Response To Gamma Radiation Response To Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Signaling Regulation Of Rap Protein Signal Transduction Response To Testosterone Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Starvation Negative Regulation Of Apoptotic Process Mast Cell Degranulation Response To Ethanol Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Symbiont Entry Into Host Cell Positive Regulation Of Receptor-mediated Endocytosis Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin-dependent Endocytosis Cellular Response To Hypoxia Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Immune System Process Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Respiratory Gaseous Exchange By Respiratory System Respiratory Tube Development Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade
Pathways		Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Negative regulation of FLT3 FLT3 signaling by CBL mutants
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 22139419 32888494 33545615) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 33339817)
Interacting Genes		130 interacting genes: ABL1 APPL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CBLIF CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR EPS8 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB1 FYN GRAP2 GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 JAK2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C MZF1 NCK1 NECTIN1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PLK1 PRKCA PRKCQ PTEN PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SERPINA5 SH2B2 SH3KBP1 SHC1 SLA SLA2 SMAD7 SORBS1 SORBS2 SP7 SPRY2 SRC STAP2 STAT3 STAT5A STAT5B SYK TCN1 TCN2 TGM2 TNFRSF11A TRAF4 TRAF6 TRIM8 TYK2 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2M UBE2N UBE2U UBE2W USP21 VAV1 VAV2 WWP1 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	137 interacting genes: ABI3 ACTMAP ALKBH4 ANXA1 AR ATOSB ATOX1 BACH2 BAHD1 BANP BCKDK BCL6B BEGAIN BEX3 BYSL CALCOCO2 CAV1 CBL CBLC CCHCR1 CENPE CEP85 CHEK1 CHUK DISC1 DNM2 DPEP2NB DTX3 EXOC7 EYA2 EZHIP FAM90A1 FAT1 FBXL18 FRS3 FTH1 GOLGA2 GOLGA6A GOLGA6L9 GORASP1 GORASP2 GPRASP1 HEY2 HGS HMG20A HOMEZ HOXA1 HOXB5 IRAK1 IRS1 ISYNA1 KANK2 KANSL1 KDM1A KRT31 KRT36 LENG8 LNX1 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NHERF2 NOS1AP NPAS2 NTRK1 NUDT16L1 OGT PCSK5 PDE4DIP PHLDA1 PICK1 PKD1P1 PLAGL2 PLEKHA7 PLSCR1 POLR2J POLR2J3 PSMC3 QARS1 RAD54L2 RBPMS REXO1L6P RNF114 RNF144B RNF4 RPS6KB1 SF3B4 SIGLEC7 SMURF1 SMURF2 SNRPB SORBS2 SPDL1 SUMO1 TARBP2 TAX1BP1 TBC1D7 TBC1D8 TFAP4 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM27 TRIM37 TSGA10IP TYK2 UBC UBE2D1 UBE2I UBL4A UBL4B USP7 VPS52 WBP11 WWP1 WWP2 ZBTB16 ZBTB26 ZC3H12C ZMYM5 ZNF177 ZNF275 ZNF3 ZNF512B ZNF559-ZNF177 ZNF581 ZNF620 ZNF688 ZNF784 ZNF835 ZRANB1
Entrez ID		867	9618
HPRD ID		01320	03915
Ensembl ID		ENSG00000110395	ENSG00000076604
Uniprot IDs		P22681	Q9BUZ4
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 5HKW 5HKX 5HKY 5HKZ 5HL0 5J3X 5O76 6O02 6O03 6XAR 7SIY	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Plasma Membrane Activation Of Immune Response Cell Activation Leukocyte Activation Positive Regulation Of MAPK Cascade Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Lymphocyte Activation Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding Fc Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Activation Regulation Of Lymphocyte Activation Cell Migration Protein Phosphorylation Phosphorylation Nucleotide Binding Transmembrane Receptor Protein Tyrosine Kinase Activity	Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Cytosol Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Identical Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination PML Body Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Biosynthetic Process Signaling Adaptor Activity Zinc Ion Binding Proteolysis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process
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