CBL and KDR

Number of citations of the paper that reports this interaction (PMID 12649282)
26

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro)

		CBL	KDR
Gene Name		Cbl proto-oncogene, E3 ubiquitin protein ligase	kinase insert domain receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Flotillin Complex	Extracellular Region Nucleus Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Membrane Raft Sorting Endosome
	Molecular Function	Phosphotyrosine Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ephrin Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Growth Factor Binding Vascular Endothelial Growth Factor Binding Hsp90 Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis	Angiogenesis Ovarian Follicle Development Vasculogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Mesenchymal Cell Proliferation Endothelium Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Extracellular Matrix Organization Positive Regulation Of Cell Migration Embryonic Hemopoiesis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Surfactant Homeostasis Positive Regulation Of MAPK Cascade Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Cell Maturation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Focal Adhesion Assembly Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Signaling by the B Cell Receptor (BCR) Loss of Function of TGFBR2 in Cancer Signaling by FGFR in disease SMAD2/3 MH2 Domain Mutants in Cancer Interleukin-6 signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Negative regulation of FGFR signaling EGFR downregulation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer Spry regulation of FGF signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Loss of Function of TGFBR1 in Cancer Signaling by FGFR Signaling by EGFR Signaling by Interleukins Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by EGFR in Cancer Constitutive Signaling by EGFRvIII Interleukin-3, 5 and GM-CSF signaling SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	VEGF binds to VEGFR leading to receptor dimerization EPHA-mediated growth cone collapse VEGF ligand-receptor interactions Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF EPH-Ephrin signaling Neurophilin interactions with VEGF and VEGFR Integrin cell surface interactions VEGFA-VEGFR2 Pathway
Drugs			Sorafenib Sunitinib N-(4-{4-AMINO-6-[4-(METHYLOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-5-YL}PHENYL)-N\'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA Pazopanib Axitinib 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one N\'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Cabozantinib Regorafenib Ponatinib
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	49 interactors: ACP1 AIMP2 ANXA5 ATR BMX BTRC CAV1 CBL CDH5 COL18A1 CRK CSF2RB CSNK1D CTNNB1 DNM2 FBXO25 FBXW11 FIGF FLT1 FLT4 FRS2 FYN GNA11 GNAQ GRB10 GRB2 HSP90AA1 IQGAP1 ITGB3 NCK1 NRP1 P2RY2 PLCG1 PLCG2 PTPN11 PTPN6 RASA1 SH2D2A SHB SHC1 SHC2 SRC STAT1 SYNGAP1 TIMP3 UBC VEGFA VEGFC YES1
Entrez ID		867	3791
HPRD ID		01320	01867
Ensembl ID		ENSG00000110395	ENSG00000128052
Uniprot IDs		P22681	P35968
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL	1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune System Process Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Innate Immune Response Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Defense Response Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Immune Response Regulation Of Signaling Signaling Cell Communication Response To Organic Substance Cellular Response To Organic Substance Cell Activation Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Response To Growth Factor Regulation Of Cell Activation Cellular Response To Stimulus Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Migration Locomotion Regulation Of Intracellular Signal Transduction Cell Motility Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Movement Of Cell Or Subcellular Component Wound Healing	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Body Fluid Levels Response To Growth Factor Anatomical Structure Morphogenesis Response To Wounding Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Platelet Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process System Development Response To Organic Substance Cardiovascular System Development Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Development Cell Differentiation Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Leukocyte Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Blood Vessel Development Cellular Response To Peptide Positive Regulation Of Metabolic Process Angiogenesis
Tagcloud ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Difference) ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	accepted aorta cd34 cd45 clustered coexpress embryo emerge flk gata genesis gonad hematogenous hematopoietic library lin mesoderm mesonephros myb para primitive sac sorted strikingly territory therefrom ventral vertebrate yolk
Tagcloud (Intersection) ?