CBL and CD38

Number of citations of the paper that reports this interaction (PMID 18974118)
10

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology, fluorescent resonance energy transfer)

		CBL	CD38
Gene Name		Cbl proto-oncogene, E3 ubiquitin protein ligase	CD38 molecule
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Flotillin Complex	Nucleus Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ephrin Receptor Binding	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity NAD(P)+ Nucleosidase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long Term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Loss of Function of TGFBR2 in Cancer Signaling by FGFR in disease SMAD2/3 MH2 Domain Mutants in Cancer Interleukin-6 signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Negative regulation of FGFR signaling EGFR downregulation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer Spry regulation of FGF signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Loss of Function of TGFBR1 in Cancer Signaling by FGFR Signaling by EGFR Signaling by Interleukins Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by EGFR in Cancer Constitutive Signaling by EGFRvIII Interleukin-3, 5 and GM-CSF signaling SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	6 interactors: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		867	952
HPRD ID		01320	00116
Ensembl ID		ENSG00000110395
Uniprot IDs		P22681	P28907
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4F45 4F46
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune System Process Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Innate Immune Response Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Defense Response Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Immune Response Regulation Of Signaling Signaling Cell Communication Response To Organic Substance Cellular Response To Organic Substance Cell Activation Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Response To Growth Factor Regulation Of Cell Activation Cellular Response To Stimulus Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Migration Locomotion Regulation Of Intracellular Signal Transduction Cell Motility Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Movement Of Cell Or Subcellular Component Wound Healing	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cell Activation Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Positive Regulation Of JAK-STAT Cascade Blood Coagulation Positive Regulation Of Signal Transduction Hemostasis Regulation Of Immune System Process Platelet Degranulation Immune Response-regulating Signaling Pathway T Cell Costimulation Regulation Of Cellular Ketone Metabolic Process Regulation Of Defense Response To Virus Regulation Of JAK-STAT Cascade Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Body Fluid Levels Wound Healing T Cell Receptor Signaling Pathway Response To Stress Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Antigen Receptor-mediated Signaling Pathway Diapedesis Positive Regulation Of Protein Phosphorylation T Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Phosphorylation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of T Cell Activation
Tagcloud ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	alters apl cd18 changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml proline promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged
Tagcloud (Difference) ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine sh2 sh3 thymoma tyr731 yeam	alters apl cd18 changing coexpressed confirms develops engineered fuses heterodimerize hl60 leucine lost nb4 pml promyelocytic r4 rar rares relapsed relieved repressed retain retains retinoid subclone subclones unrearranged
Tagcloud (Intersection) ?		proline