CBL and CD38

Number of citations of the paper that reports this interaction (PubMedID 19635790)
54

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology, fluorescent resonance energy transfer)

		CBL	CD38
Description		Cbl proto-oncogene	CD38 molecule
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Membrane Flotillin Complex Axon Growth Cone Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Nuclear Membrane Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cadherin Binding Metal Ion Binding Ephrin Receptor Binding Ubiquitin Protein Ligase Activity Protein Tyrosine Kinase Binding	Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Signal Transduction Cell Surface Receptor Signaling Pathway Male Gonad Development Response To Gamma Radiation Response To Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Signaling Regulation Of Rap Protein Signal Transduction Response To Testosterone Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Starvation Negative Regulation Of Apoptotic Process Mast Cell Degranulation Response To Ethanol Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Symbiont Entry Into Host Cell Positive Regulation Of Receptor-mediated Endocytosis Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin-dependent Endocytosis Cellular Response To Hypoxia Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD+ Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Cytokine B Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Negative regulation of FLT3 FLT3 signaling by CBL mutants	Nicotinate metabolism
Drugs			Daratumumab Isatuximab Mezagitamab
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 22139419 32888494 33545615) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 33339817)	Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)
Interacting Genes		130 interacting genes: ABL1 APPL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CBLIF CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR EPS8 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB1 FYN GRAP2 GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 JAK2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C MZF1 NCK1 NECTIN1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PLK1 PRKCA PRKCQ PTEN PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SERPINA5 SH2B2 SH3KBP1 SHC1 SLA SLA2 SMAD7 SORBS1 SORBS2 SP7 SPRY2 SRC STAP2 STAT3 STAT5A STAT5B SYK TCN1 TCN2 TGM2 TNFRSF11A TRAF4 TRAF6 TRIM8 TYK2 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2M UBE2N UBE2U UBE2W USP21 VAV1 VAV2 WWP1 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		867	952
HPRD ID		01320	00116
Ensembl ID		ENSG00000110395	ENSG00000004468
Uniprot IDs		P22681	B4E006 P28907
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 5HKW 5HKX 5HKY 5HKZ 5HL0 5J3X 5O76 6O02 6O03 6XAR 7SIY	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA 7DHA 7DUO 7VKE 8BYU 8D0M 8IL3 8P8C 8VAU 9GOX 9GOY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Plasma Membrane Activation Of Immune Response Cell Activation Leukocyte Activation Positive Regulation Of MAPK Cascade Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Lymphocyte Activation Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding Fc Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Activation Regulation Of Lymphocyte Activation Cell Migration Protein Phosphorylation Phosphorylation Nucleotide Binding Transmembrane Receptor Protein Tyrosine Kinase Activity	Platelet Alpha Granule Membrane Membrane Raft External Side Of Plasma Membrane Plasma Membrane Cell Activation Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Leukocyte Degranulation Protein Tyrosine Kinase Binding Phosphotyrosine Residue Binding Cell Adhesion Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Lymphocyte Activation Clathrin-coated Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Positive Regulation Of Cell Activation Helper T Cell Enhancement Of Adaptive Immune Response Platelet Activation Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endocytosis Positive Regulation Of MAPK Cascade Lymphocyte Activation Regulated Exocytosis Response To Methamphetamine Hydrochloride Regulation Of Cell-cell Adhesion Low-affinity IgG Receptor Activity Immune Receptor Activity Endothelial Cell-matrix Adhesion Regulation Of Lymphocyte Activation Response To Ethanol Symbiont Entry Into Host Cell Cell Recognition Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Activation Myoblast Fusion Involved In Skeletal Muscle Regeneration Fc-gamma Receptor III Complex Import Into Cell Regulation Of Rap Protein Signal Transduction Membrane Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation CD8 Receptor Binding Positive Regulation Of Protein Localization To Cell-cell Junction
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