CBL and CD19

Number of citations of the paper that reports this interaction (PubMedID 9178909)
0

Data Source:
HPRD (in vivo)

		CBL	CD19
Description		Cbl proto-oncogene	CD19 molecule
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Membrane Flotillin Complex Axon Growth Cone Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cadherin Binding Metal Ion Binding Ephrin Receptor Binding Ubiquitin Protein Ligase Activity Protein Tyrosine Kinase Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Signal Transduction Cell Surface Receptor Signaling Pathway Male Gonad Development Response To Gamma Radiation Response To Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Signaling Regulation Of Rap Protein Signal Transduction Response To Testosterone Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Starvation Negative Regulation Of Apoptotic Process Mast Cell Degranulation Response To Ethanol Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Symbiont Entry Into Host Cell Positive Regulation Of Receptor-mediated Endocytosis Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin-dependent Endocytosis Cellular Response To Hypoxia Regulation Of Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	B-1 B Cell Differentiation Adaptive Immune Response B Cell Proliferation Involved In Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity B Cell Proliferation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Negative regulation of FLT3 FLT3 signaling by CBL mutants	PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Coltuximab ravtansine Blinatumomab Depatuxizumab mafodotin Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel Loncastuximab tesirine Lisocabtagene maraleucel
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 22139419 32888494 33545615) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 33339817)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		130 interacting genes: ABL1 APPL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CBLIF CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR EPS8 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB1 FYN GRAP2 GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 JAK2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C MZF1 NCK1 NECTIN1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PLK1 PRKCA PRKCQ PTEN PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SERPINA5 SH2B2 SH3KBP1 SHC1 SLA SLA2 SMAD7 SORBS1 SORBS2 SP7 SPRY2 SRC STAP2 STAT3 STAT5A STAT5B SYK TCN1 TCN2 TGM2 TNFRSF11A TRAF4 TRAF6 TRIM8 TYK2 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2L3 UBE2M UBE2N UBE2U UBE2W USP21 VAV1 VAV2 WWP1 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2
Entrez ID		867	930
HPRD ID		01320	00113
Ensembl ID		ENSG00000110395	ENSG00000177455
Uniprot IDs		P22681	P15391
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 5HKW 5HKX 5HKY 5HKZ 5HL0 5J3X 5O76 6O02 6O03 6XAR 7SIY	6AL5 7JIC 7URV 7URX
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Plasma Membrane Activation Of Immune Response Cell Activation Leukocyte Activation Positive Regulation Of MAPK Cascade Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Lymphocyte Activation Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding Fc Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Activation Regulation Of Lymphocyte Activation Cell Migration Protein Phosphorylation Phosphorylation Nucleotide Binding Transmembrane Receptor Protein Tyrosine Kinase Activity	Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Lymphocyte Activation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response B Cell Activation Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Effector Process Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Activation B Cell Proliferation Plasma Membrane Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Mononuclear Cell Differentiation Mononuclear Cell Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response Leukocyte Differentiation Lymphocyte Differentiation Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Cellular Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Defense Response
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