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CBL and CRKL
Number of citations of the paper that reports this interaction (PubMedID
12244174
)
0
Data Source:
HPRD
(in vitro, in vivo)
CBL
CRKL
Description
Cbl proto-oncogene
CRK like proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Membrane
Flotillin Complex
Axon
Growth Cone
Cell Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleoplasm
Cytoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Synapse
Extrinsic Component Of Postsynaptic Membrane
Molecular Function
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
SH3 Domain Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Metal Ion Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Binding
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Identical Protein Binding
Cadherin Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Signaling
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Symbiont Entry Into Host Cell
Positive Regulation Of Receptor-mediated Endocytosis
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ubiquitin-dependent Endocytosis
Cellular Response To Hypoxia
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Regulation Of Leukocyte Migration
Outflow Tract Morphogenesis
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Pattern Specification Process
Heart Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Animal Organ Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Migration
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Intracellular Signal Transduction
Helper T Cell Diapedesis
Reelin-mediated Signaling Pathway
Positive Regulation Of MAPK Cascade
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Fibroblast Growth Factor
Endothelin Receptor Signaling Pathway
Acetylcholine Receptor Signaling Pathway
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Chordate Pharynx Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Pathways
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by CSF1 (M-CSF) in myeloid cells
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
27863252
29403010
22139419
32888494
33545615
)
Plateletcrit (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Triglyceride levels (
33339817
)
Mean platelet volume (
32888494
)
Platelet distribution width (
27863252
32888494
)
Interacting Genes
130 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PLK1
PRKCA
PRKCQ
PTEN
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
WWP1
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
78 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
Entrez ID
867
1399
HPRD ID
01320
03596
Ensembl ID
ENSG00000110395
ENSG00000099942
Uniprot IDs
P22681
P46109
PDB IDs
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
6XAR
7SIY
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune System Process
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Plasma Membrane
Activation Of Immune Response
Cell Activation
Leukocyte Activation
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Lymphocyte Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
ATP Binding
Fc Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Transferase Activity
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Cell Migration
Protein Phosphorylation
Phosphorylation
Nucleotide Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
SH3 Domain Binding
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Immune System Process
Insulin Receptor Signaling Pathway
Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Leukocyte Activation
Immune Effector Process
ERBB Signaling Pathway
B Cell Receptor Signaling Pathway
Lymphocyte Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
Cytosol
Regulation Of Immune System Process
B Cell Differentiation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
B Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of MAPK Cascade
Cell Migration
Cellular Response To Growth Factor Stimulus
Plasma Membrane
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Protein Tyrosine Kinase Binding
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Protein Kinase Activity
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Growth Hormone Receptor Signaling Pathway
T Cell Activation
Regulation Of Signaling
Regulation Of Cell Communication
Response To Growth Factor
Regulation Of Multicellular Organismal Development
Ephrin Receptor Binding
Regulation Of Leukocyte Proliferation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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