CBL and SH3KBP1

Number of citations of the paper that reports this interaction (PMID 11894095)
124

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CBL	SH3KBP1
Gene Name		Cbl proto-oncogene, E3 ubiquitin protein ligase	SH3-domain kinase binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Flotillin Complex	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Phosphotyrosine Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ephrin Receptor Binding	Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Loss of Function of TGFBR2 in Cancer Signaling by FGFR in disease SMAD2/3 MH2 Domain Mutants in Cancer Interleukin-6 signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Negative regulation of FGFR signaling EGFR downregulation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer Spry regulation of FGF signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Loss of Function of TGFBR1 in Cancer Signaling by FGFR Signaling by EGFR Signaling by Interleukins Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by EGFR in Cancer Constitutive Signaling by EGFRvIII Interleukin-3, 5 and GM-CSF signaling SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219
Entrez ID		867	30011
HPRD ID		01320	02301
Ensembl ID		ENSG00000110395	ENSG00000147010
Uniprot IDs		P22681	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL	2BZ8 2K6D 2K9G 2O2O 2YDL
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune System Process Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Innate Immune Response Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Defense Response Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Immune Response Regulation Of Signaling Signaling Cell Communication Response To Organic Substance Cellular Response To Organic Substance Cell Activation Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Response To Growth Factor Regulation Of Cell Activation Cellular Response To Stimulus Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Migration Locomotion Regulation Of Intracellular Signal Transduction Cell Motility Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Movement Of Cell Or Subcellular Component Wound Healing	Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response
Tagcloud ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		32dcl3 32p antisera eliminated engagement fusion gst immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 git1 lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?		fyn hck