CBL and PIK3R1

  • Number of citations of the paper that reports this interaction (PMID 7642581)
  • 29
  • Data Source:
  • BioGRID (affinity chromatography technology, enzymatic study)
  • HPRD (in vivo, in vitro)

CBL

PIK3R1

Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease biomarkers ( 23419831)
  • Menarche (age at onset) ( 23599027)
Protein-Protein Interactions 114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 149 interactors: ABL1 ADAM12 ADAMTS2 AGAP2 AKT1 ALK ANK3 ARAF ARHGAP1 ARHGAP17 ARHGAP32 AXL BCAR1 BRCA1 CBL CBLB CCL14 CD19 CD22 CD28 CD2AP CD3E CD4 CD40 CD5 CD7 CDC42 CDH2 CHRNA7 CRK CRKL CSF1R CSF2RA CTLA4 CTNNB1 CXCL2 CYP4A11 DLX2 DNM1 DOK1 EGFR EPHA2 EPOR ERAS ERBB2 ERBB3 ESR1 EZR FASLG FCGR2A FES FGFR1 FYN GAB1 GAB2 GAB3 GHR GRB2 GSK3B GSPT1 GTF2H1 HCK HCST HDAC1 HGS HOXA1 HRAS HTT IFNAR1 IGF1R IL13 IL1R1 IL1RAP IL2RB IL7R INPP4A INSR IRS1 IRS2 IRS4 ITSN1 JAK1 JAK2 JAK3 KHDRBS1 KIT LAT LCK LCP2 MAPK8 MET MME MST1R NFKBIA NTRK1 NTRK2 NUP85 PDGFRA PDGFRB PECAM1 PFN1 PIK3AP1 PIK3CA PIK3CB PIK3CD PPM1A PSEN1 PSMB5 PTK2 PTK2B PTPN11 PTPN6 RAC1 RASA1 RB1 RET RRAS2 SH3KBP1 SHB SHC1 SLC9A2 SOCS1 SOCS6 SOCS7 SRC SSTR2 SYK SYN1 TEC TEK TGFBR1 TGFBR2 TIE1 TLR2 TOM1L1 TRAT1 TSHR TTR TUB TUBA1B TUBG1 TYK2 TYRO3 VAV1 VAV3 WAS WASF3 WBP11 YWHAG
Entrez ID 867 5295
HPRD ID 01320 01381
Ensembl ID ENSG00000110395 ENSG00000145675
Uniprot IDs P22681 P27986
PDB IDs 1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
16q  1q  affymetrix  classic  clustering  clusters  cytoskeleton  distinguished  epithelium  fresh  frozen  golm1  gpr137b  hierarchical  ilc  lcis  lobular  mastectomy  microarrays  microdissected  obligate  personalize  precursor  prophylactic  supervised  transcriptomic  triplets  u133a  unsupervised 
Tagcloud (Difference) ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
16q  1q  affymetrix  classic  clustering  clusters  cytoskeleton  distinguished  epithelium  fresh  frozen  golm1  gpr137b  hierarchical  ilc  lcis  lobular  mastectomy  microarrays  microdissected  obligate  personalize  precursor  prophylactic  supervised  transcriptomic  triplets  u133a  unsupervised 
Tagcloud (Intersection) ?