TRAF4 and BCKDK

Number of citations of the paper that reports this interaction (PMID 12023963)
16

Data Source:
HPRD (two hybrid)

		TRAF4	BCKDK
Gene Name		TNF receptor-associated factor 4	branched chain ketoacid dehydrogenase kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Phosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581	6 interactors: APP EPS8 LSM8 NR5A2 STAT3 TRAF4
Entrez ID		9618	10295
HPRD ID		03915	12523
Ensembl ID		ENSG00000076604	ENSG00000103507
Uniprot IDs		Q9BUZ4	A8MY43 O14874 Q96G95
PDB IDs		2EOD 2YUC 4M4E
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process	Intracellular Receptor Signaling Pathway Feeding Behavior Regulation Of Multicellular Organism Growth Behavior Adult Locomotory Behavior Synaptic Growth At Neuromuscular Junction Response To Ethanol Regulation Of Protein Binding Adult Behavior Collateral Sprouting In Absence Of Injury Actin Polymerization-dependent Cell Motility Chemical Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Locomotory Behavior Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Exit From Mitosis Steroid Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Negative Regulation Of Glycolytic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Regulation Of Signal Transduction Neuron Remodeling Radial Glial Cell Differentiation Behavioral Response To Ethanol Positive Regulation Of Protein Homodimerization Activity Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Development Positive Regulation Of Transcription, DNA-templated Organ Development Homeostatic Process Regulation Of Signaling Interleukin-6-mediated Signaling Pathway Signaling Cell Communication RNA Metabolic Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Regulation Of Protein Homodimerization Activity Positive Regulation Of Metabolic Process Single-organism Behavior
Tagcloud ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected	administering afforded akt3 ameliorated asd autism autisms clues cntn5 cntnap2 cyfip1 en2 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1
Tagcloud (Difference) ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected	administering afforded akt3 ameliorated asd autism autisms clues cntn5 cntnap2 cyfip1 en2 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1
Tagcloud (Intersection) ?