TRAF4 and TBC1D8

Number of citations of the paper that reports this interaction (PMID 12023963)
16

Data Source:
HPRD (two hybrid)

		TRAF4	TBC1D8
Gene Name		TNF receptor-associated factor 4	TBC1 domain family, member 8 (with GRAM domain)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm	Membrane
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding	Rab GTPase Activator Activity
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity	Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Rab GTPase Activity Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS			Osteoporosis ( 20548944)
Protein-Protein Interactions		69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581	2 interactors: SPP1 TRAF4
Entrez ID		9618	11138
HPRD ID		03915	06752
Ensembl ID		ENSG00000076604	ENSG00000204634
Uniprot IDs		Q9BUZ4	J3KQ40 O95759
PDB IDs		2EOD 2YUC 4M4E
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D NIK/NF-kappaB Signaling Regulation Of Bone Resorption Regulation Of NIK/NF-kappaB Signaling Maternal Placenta Development Regulation Of Bone Remodeling Neutrophil Chemotaxis Neutrophil Migration Respiratory Gaseous Exchange Granulocyte Chemotaxis Negative Regulation Of Axonogenesis Positive Regulation Of Protein Binding Regulation Of Tissue Remodeling Biomineral Tissue Development Embryo Implantation Maternal Process Involved In Female Pregnancy Negative Regulation Of Developmental Growth Extracellular Matrix Disassembly Negative Regulation Of Cell Morphogenesis Involved In Differentiation Leukocyte Chemotaxis Response To Vitamin Positive Regulation Of JNK Cascade Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Binding Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Size Osteoblast Differentiation Negative Regulation Of Cell Projection Organization Regulation Of Protein Binding Negative Regulation Of Cell Growth Regulation Of Axonogenesis Regulation Of JNK Cascade Cell Chemotaxis
Tagcloud ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Difference) ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected
Tagcloud (Intersection) ?