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TRAF4 and TBC1D8
Number of citations of the paper that reports this interaction (PMID
12023963
)
16
Data Source:
HPRD
(two hybrid)
TRAF4
TBC1D8
Gene Name
TNF receptor-associated factor 4
TBC1 domain family, member 8 (with GRAM domain)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytoskeleton
Plasma Membrane
Tight Junction
Perinuclear Region Of Cytoplasm
Membrane
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
WW Domain Binding
Rab GTPase Activator Activity
Biological Process
Apoptotic Process
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Respiratory Gaseous Exchange
Protein Ubiquitination
Respiratory Tube Development
Regulation Of Apoptotic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Protein Homodimerization Activity
Blood Circulation
Positive Regulation Of Cell Proliferation
Positive Regulation Of Rab GTPase Activity
Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS
Osteoporosis (
20548944
)
Protein-Protein Interactions
69 interactors:
ALKBH4
ARNT2
BAHD1
BANP
BCKDK
BCL6B
BYSL
CALCOCO2
CBL
CBLC
CCHCR1
CENPE
CHUK
DTX3
EXOC7
FBXL18
FTH1
GORASP2
GPRASP1
HOMEZ
IRAK1
ISYNA1
KANSL1
KDM1A
KRT31
KRT40
LTBR
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NGFRAP1
NOS1AP
NPAS2
PDE4DIP
PKD1P1
PLSCR1
PSMC3
QARS
REXO1L6P
RNF114
RPS6KB1
SIGLEC7
SMURF1
SMURF2
SORBS2
SPDL1
SUMO1
TARBP2
TBC1D7
TBC1D8
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM37
TYK2
UBE2I
UBL4A
UBL4B
USP7
WBP11
WWP1
WWP2
ZNF3
ZNF512B
ZNF581
2 interactors:
SPP1
TRAF4
Entrez ID
9618
11138
HPRD ID
03915
06752
Ensembl ID
ENSG00000076604
ENSG00000204634
Uniprot IDs
Q9BUZ4
J3KQ40
O95759
PDB IDs
2EOD
2YUC
4M4E
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Signaling
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Response To Growth Factor
Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Cellular Protein Modification Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Response To Organic Substance
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Programmed Cell Death
Proteolysis Involved In Cellular Protein Catabolic Process
Response To Cytokine
Cellular Protein Catabolic Process
Cell Death
Death
Protein Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Protein Catabolic Process
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Negative Regulation Of Collateral Sprouting
Negative Regulation Of Axon Regeneration
Positive Regulation Of Protein Homodimerization Activity
Positive Regulation Of Bone Resorption
Regulation Of Axon Regeneration
Regulation Of Protein Homodimerization Activity
Activation Of NF-kappaB-inducing Kinase Activity
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Tissue Remodeling
Decidualization
Response To Vitamin D
NIK/NF-kappaB Signaling
Regulation Of Bone Resorption
Regulation Of NIK/NF-kappaB Signaling
Maternal Placenta Development
Regulation Of Bone Remodeling
Neutrophil Chemotaxis
Neutrophil Migration
Respiratory Gaseous Exchange
Granulocyte Chemotaxis
Negative Regulation Of Axonogenesis
Positive Regulation Of Protein Binding
Regulation Of Tissue Remodeling
Biomineral Tissue Development
Embryo Implantation
Maternal Process Involved In Female Pregnancy
Negative Regulation Of Developmental Growth
Extracellular Matrix Disassembly
Negative Regulation Of Cell Morphogenesis Involved In Differentiation
Leukocyte Chemotaxis
Response To Vitamin
Positive Regulation Of JNK Cascade
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Cell-substrate Adhesion
Positive Regulation Of Binding
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Cell Size
Osteoblast Differentiation
Negative Regulation Of Cell Projection Organization
Regulation Of Protein Binding
Negative Regulation Of Cell Growth
Regulation Of Axonogenesis
Regulation Of JNK Cascade
Cell Chemotaxis
Tagcloud
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Difference)
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Intersection)
?