Wiki-Pi
About
Search
People
Updates
Search
CBL and PLK1
Number of citations of the paper that reports this interaction (PubMedID
37174055
)
33
Data Source:
BioGRID
(enzymatic study)
CBL
PLK1
Description
Cbl proto-oncogene
polo like kinase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Membrane
Flotillin Complex
Axon
Growth Cone
Cell Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Chromosome, Centromeric Region
Kinetochore
Condensed Chromosome, Centromeric Region
Chromatin
Synaptonemal Complex
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Molecular Function
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
SH3 Domain Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Metal Ion Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Binding
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Serine Kinase Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Signaling
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Symbiont Entry Into Host Cell
Positive Regulation Of Receptor-mediated Endocytosis
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ubiquitin-dependent Endocytosis
Cellular Response To Hypoxia
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Division
Mitotic Cytokinesis
Double-strand Break Repair Via Homologous Recombination
Microtubule Bundle Formation
Double-strand Break Repair
Protein Phosphorylation
Mitotic Spindle Organization
Sister Chromatid Cohesion
Mitotic Chromosome Condensation
Mitotic Nuclear Membrane Disassembly
Metaphase/anaphase Transition Of Mitotic Cell Cycle
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Protein Localization To Organelle
Negative Regulation Of Apoptotic Process
Homologous Chromosome Segregation
Establishment Of Protein Localization
Positive Regulation Of Proteolysis
Golgi Inheritance
Nuclear Membrane Disassembly
Centrosome Separation
Cell Division
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Protein Localization To Centrosome
Protein Localization To Nuclear Envelope
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by CSF1 (M-CSF) in myeloid cells
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Volasertib
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
27863252
29403010
22139419
32888494
33545615
)
Plateletcrit (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Triglyceride levels (
33339817
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
130 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PLK1
PRKCA
PRKCQ
PTEN
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
WWP1
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
147 interacting genes:
-
ACTL6B
AKAP12
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
C6orf136
CBL
CCNB1
CDC14A
CDC25C
CDC6
CEBPA
CENPQ
CENPU
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
CUL4B
DNAJB9
DNHD1
ECT2
EIF6
ERCC6L
EYA1
EYA4
FBXL5
FBXW7
GET4
GLB1
GORASP1
HNRNPU
IDH1
IDH2
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRABD3
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MISP
MPP2
MYC
MYT1
NCAPD3
NCAPG2
NCAPH2
NEDD1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PON1
PPID
PPIL2
PPP1R12A
PPP6R2
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PSRC1
PTEN
PTPRD
RAB1A
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RSF1
RXRA
SEPTIN9
SHCBP1
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STUB1
SUGT1
TIMELESS
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
UBE2I
UHRF1
USP16
USP7
VIM
VMA22
VRK2
VRK3
WAC
WEE1
ZNF71
Entrez ID
867
5347
HPRD ID
01320
03652
Ensembl ID
ENSG00000110395
ENSG00000166851
Uniprot IDs
P22681
P53350
PDB IDs
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
6XAR
7SIY
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
7MSO
7MX1
8BJT
8CRC
8JOQ
8JOY
8S30
8S31
8WFP
8X72
8XB9
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune System Process
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Plasma Membrane
Activation Of Immune Response
Cell Activation
Leukocyte Activation
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Lymphocyte Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
ATP Binding
Fc Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Transferase Activity
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Cell Migration
Protein Phosphorylation
Phosphorylation
Nucleotide Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Proteasome Core Complex
Cell Division
Cytoplasm
Regulation Of Cell Cycle
Nucleoplasm
Regulation Of Cell Cycle Process
Nucleus
Cytosol
Cellular Response To Stress
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteasome Complex
Proteasomal Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response
Macromolecule Catabolic Process
Positive Regulation Of Cell Cycle
Proteasome Core Complex, Beta-subunit Complex
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle
Spindle
Regulation Of Cell Cycle Phase Transition
Proteasome Core Complex, Alpha-subunit Complex
Regulation Of Cellular Response To Stress
Microtubule-based Process
Organelle Organization
Centrosome
Cytoskeleton
Microtubule Cytoskeleton Organization
Midbody
Proteolysis
Regulation Of Intracellular Signal Transduction
Cellular Response To Radiation
DNA Repair
Chromosome Segregation
Regulation Of Chromosome Organization
Regulation Of Cytokinesis
Macromolecule Metabolic Process
Response To Xenobiotic Stimulus
Regulation Of Organelle Organization
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Chromosome Segregation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cell Cycle
Positive Regulation Of Programmed Cell Death
Protein Kinase Binding
Chromosome
Regulation Of Chromosome Segregation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?