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TRAF4 and DTX3
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
TRAF4
DTX3
Gene Name
TNF receptor-associated factor 4
deltex 3, E3 ubiquitin ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytoskeleton
Plasma Membrane
Tight Junction
Perinuclear Region Of Cytoplasm
Cytoplasm
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
WW Domain Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Apoptotic Process
Signal Transduction
Activation Of NF-kappaB-inducing Kinase Activity
Respiratory Gaseous Exchange
Protein Ubiquitination
Respiratory Tube Development
Regulation Of Apoptotic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of Protein Homodimerization Activity
Notch Signaling Pathway
Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
69 interactors:
ALKBH4
ARNT2
BAHD1
BANP
BCKDK
BCL6B
BYSL
CALCOCO2
CBL
CBLC
CCHCR1
CENPE
CHUK
DTX3
EXOC7
FBXL18
FTH1
GORASP2
GPRASP1
HOMEZ
IRAK1
ISYNA1
KANSL1
KDM1A
KRT31
KRT40
LTBR
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NGFRAP1
NOS1AP
NPAS2
PDE4DIP
PKD1P1
PLSCR1
PSMC3
QARS
REXO1L6P
RNF114
RPS6KB1
SIGLEC7
SMURF1
SMURF2
SORBS2
SPDL1
SUMO1
TARBP2
TBC1D7
TBC1D8
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM37
TYK2
UBE2I
UBL4A
UBL4B
USP7
WBP11
WWP1
WWP2
ZNF3
ZNF512B
ZNF581
25 interactors:
DTX1
DTX2
RNF141
RNF38
TRAF4
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2DNL
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2K
UBE2L3
UBE2L6
UBE2V1
UBE2W
UEVLD
USP1
USP2
USP21
XIAP
ZDHHC17
Entrez ID
9618
196403
HPRD ID
03915
16842
Ensembl ID
ENSG00000076604
ENSG00000178498
Uniprot IDs
Q9BUZ4
Q8N9I9
PDB IDs
2EOD
2YUC
4M4E
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Protein Ubiquitination
Regulation Of Gene Expression
Regulation Of Signal Transduction
Regulation Of Metabolic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Signaling
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Response To Growth Factor
Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Cellular Protein Modification Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Response To Organic Substance
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Programmed Cell Death
Proteolysis Involved In Cellular Protein Catabolic Process
Response To Cytokine
Cellular Protein Catabolic Process
Cell Death
Death
Protein Metabolic Process
Cellular Response To Organic Substance
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein K11-linked Ubiquitination
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Proteolysis
ISG15-protein Conjugation
Protein K63-linked Ubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Metabolic Process
Regulation Of Proteolysis
Regulation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Cellular Response To Stress
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Protein Monoubiquitination
Activation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To DNA Damage Stimulus
Tagcloud
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Difference)
?
bcr
cart
cd40
cd54
cd95
ciap2
define
dr3
driven
effector
engagement
fas
icam
linking
mapk
mapkapk
minimal
p38
permeable
perturbed
potentiating
requirement
responsive
sb203580
selectively
stimulates
tonsillar
traf1
unaffected
Tagcloud (Intersection)
?