CBL and EPHA2

  • Number of citations of the paper that reports this interaction (PMID 12496371)
  • 40
  • Data Source:
  • HPRD (in vivo)

CBL

EPHA2

Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase EPH receptor A2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Protein-Protein Interactions 114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 30 interactors: ACP1 ADRBK1 APP CBL CDH5 CDK17 CLDN4 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR GATAD1 GRB2 KPNA3 LSM7 NUDT9 PIK3R1 PIK3R2 PSME2 PTK2 PTPN11 RASA1 RBL1 SHC1 SLA TIAM1 TNFAIP1 UBE4A
Entrez ID 867 1969
HPRD ID 01320 01494
Ensembl ID ENSG00000110395 ENSG00000142627
Uniprot IDs P22681 P29317
PDB IDs 1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
abstract  advantages  anchor  antibody  blocks  buried  cavity  cdr  consequently  crystal  deep  ephrin  ephs  forming  hydrophobic  isolate  lengthy  library  loop  mediators  phage  pocket  protrudes  reduces  reveals  stoichiometry  technology  tip 
Tagcloud (Difference) ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
abstract  advantages  anchor  antibody  blocks  buried  cavity  cdr  consequently  crystal  deep  ephrin  ephs  forming  hydrophobic  isolate  lengthy  library  loop  mediators  phage  pocket  protrudes  reduces  reveals  stoichiometry  technology  tip 
Tagcloud (Intersection) ?