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CBL and STAT3
Number of citations of the paper that reports this interaction (PubMedID
25814554
)
62
Data Source:
BioGRID
(two hybrid)
CBL
STAT3
Description
Cbl proto-oncogene
signal transducer and activator of transcription 3
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Cilium
Membrane
Flotillin Complex
Axon
Growth Cone
Cell Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrial Inner Membrane
Cytosol
Plasma Membrane
Postsynaptic Density
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Phosphotyrosine Residue Binding
Ubiquitin-protein Transferase Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
SH3 Domain Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Cadherin Binding
Metal Ion Binding
Ephrin Receptor Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
CCR5 Chemokine Receptor Binding
Nuclear Glucocorticoid Receptor Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Primary MiRNA Binding
LncRNA Binding
DNA-binding Transcription Factor Binding
Protein Sequestering Activity
RNA Sequestering Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Male Gonad Development
Response To Gamma Radiation
Response To Activity
Protein Ubiquitination
Cytokine-mediated Signaling Pathway
Regulation Of Signaling
Regulation Of Rap Protein Signal Transduction
Response To Testosterone
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Starvation
Negative Regulation Of Apoptotic Process
Mast Cell Degranulation
Response To Ethanol
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Symbiont Entry Into Host Cell
Positive Regulation Of Receptor-mediated Endocytosis
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ubiquitin-dependent Endocytosis
Cellular Response To Hypoxia
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Response To Hypoxia
Eye Photoreceptor Cell Differentiation
Regulation Of Cytokine Production
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Acute-phase Response
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Signal Transduction Involved In Regulation Of Gene Expression
Cell Differentiation
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Response To Cytokine
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-11-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Regulation Of Cell Population Proliferation
Glucose Homeostasis
Eating Behavior
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Peptide Hormone
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Leptin Stimulus
Response To Leptin
Response To Ethanol
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Negative Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Mitochondrial Membrane Permeability
Astrocyte Differentiation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Retinal Rod Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Positive Regulation Of Extracellular Matrix Disassembly
Inflammatory Response To Wounding
Energy Homeostasis
Cellular Response To Interleukin-17
Cell Surface Receptor Signaling Pathway Via STAT
Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Interleukin-10-mediated Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Cellular Response To Hypoxia
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Negative Regulation Of Primary MiRNA Processing
Negative Regulation Of Stem Cell Differentiation
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Neuron Migration
Pathways
Interleukin-6 signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Spry regulation of FGF signaling
Regulation of KIT signaling
EGFR downregulation
TGF-beta receptor signaling activates SMADs
Constitutive Signaling by EGFRvIII
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Negative regulation of MET activity
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by CSF1 (M-CSF) in myeloid cells
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Signaling by ALK
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
STAT3 nuclear events downstream of ALK signaling
Inactivation of CSF3 (G-CSF) signaling
Cytoprotection by HMOX1
Signaling by ALK fusions and activated point mutants
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
PKR-mediated signaling
Regulation of PD-L1(CD274) transcription
Drugs
ENMD-1198
OPB-111077
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
Oral cancer
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
27863252
29403010
22139419
32888494
33545615
)
Plateletcrit (
27863252
32888494
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Triglyceride levels (
33339817
)
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
23266558
21102463
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
23128233
26278503
27569725
28067908
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
20159113
31604244
24076602
22190364
21833088
)
Myocardial infarction (
33532862
)
Psoriasis (
25903422
23143594
)
Psoriasis or type 2 diabetes (trans-disease meta-analysis) (
33385400
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Interacting Genes
130 interacting genes:
ABL1
APPL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CBLIF
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
EPS8
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB1
FYN
GRAP2
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
JAK2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
MZF1
NCK1
NECTIN1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PLK1
PRKCA
PRKCQ
PTEN
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SERPINA5
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SMAD7
SORBS1
SORBS2
SP7
SPRY2
SRC
STAP2
STAT3
STAT5A
STAT5B
SYK
TCN1
TCN2
TGM2
TNFRSF11A
TRAF4
TRAF6
TRIM8
TYK2
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2M
UBE2N
UBE2U
UBE2W
USP21
VAV1
VAV2
WWP1
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
214 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DSCAM
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GAS5
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFE2L2
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RNF31
RPA2
RPL11
RPRD1B
RPS6KA1
RPS6KA3
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TAB3
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
Entrez ID
867
6774
HPRD ID
01320
00026
Ensembl ID
ENSG00000110395
ENSG00000168610
Uniprot IDs
P22681
A0A7I2V395
A0A7I2V444
A0A7I2V4C8
A0A7I2V4R2
A0A7I2V4R3
A0A7I2V552
A0A7I2YQD2
A0A7I2YQR5
P40763
PDB IDs
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
5HKW
5HKX
5HKY
5HKZ
5HL0
5J3X
5O76
6O02
6O03
6XAR
7SIY
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune System Process
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Immune Response-activating Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Plasma Membrane
Activation Of Immune Response
Cell Activation
Leukocyte Activation
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Intracellular Signal Transduction
Regulation Of Signal Transduction
Lymphocyte Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
ATP Binding
Fc Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Transferase Activity
Positive Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Cell Migration
Protein Phosphorylation
Phosphorylation
Nucleotide Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Metabolic Process
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Macromolecule Metabolic Process
Signal Transduction
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Regulation Of Multicellular Organismal Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Protein Kinase Activity
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Developmental Process
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Phosphorylation
Regulation Of Signal Transduction
Positive Regulation Of DNA-templated Transcription
Response To Lipid
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Immune System Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Immune System Process
Response To Cytokine
Phosphorylation
Kinase Activity
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Response To Peptide
Cell Surface Receptor Signaling Pathway Via STAT
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