CBL and CUBN

Number of citations of the paper that reports this interaction (PMID 15736970)
8

Data Source:
BioGRID (unspecified method)

		CBL	CUBN
Gene Name		Cbl proto-oncogene, E3 ubiquitin protein ligase	cubilin (intrinsic factor-cobalamin receptor)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Flotillin Complex	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ephrin Receptor Binding	Receptor Activity Transporter Activity Calcium Ion Binding Protein Binding Cobalamin Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis	Tissue Homeostasis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Cobalamin Transport Lipoprotein Metabolic Process Vitamin D Metabolic Process Lipoprotein Transport Small Molecule Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Loss of Function of TGFBR2 in Cancer Signaling by FGFR in disease SMAD2/3 MH2 Domain Mutants in Cancer Interleukin-6 signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Regulation of KIT signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Negative regulation of FGFR signaling EGFR downregulation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer Spry regulation of FGF signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Loss of Function of TGFBR1 in Cancer Signaling by FGFR Signaling by EGFR Signaling by Interleukins Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by EGFR in Cancer Constitutive Signaling by EGFRvIII Interleukin-3, 5 and GM-CSF signaling SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Lipoprotein metabolism Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Lipid digestion, mobilization, and transport Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Metabolism of steroid hormones and vitamin D Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism HDL-mediated lipid transport Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Vitamin D (calciferol) metabolism Defects in vitamin and cofactor metabolism
Drugs			Hydroxocobalamin
Diseases
GWAS		Platelet counts ( 22139419)	Folate pathway vitamin levels ( 19303062 19744961) MRI atrophy measures ( 21116278) Quantitative traits ( 19197348) Urinary albumin excretion ( 21355061)
Protein-Protein Interactions		114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70	9 interactors: ALB BRCA1 CBL GC GIF LGALS3 LRP2 SCGB1A1 TF
Entrez ID		867	8029
HPRD ID		01320	04296
Ensembl ID		ENSG00000110395	ENSG00000107611
Uniprot IDs		P22681	O60494
PDB IDs		1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL	3KQ4
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune System Process Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Innate Immune Response Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Defense Response Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Immune Response Regulation Of Signaling Signaling Cell Communication Response To Organic Substance Cellular Response To Organic Substance Cell Activation Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Response To Growth Factor Regulation Of Cell Activation Cellular Response To Stimulus Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Migration Locomotion Regulation Of Intracellular Signal Transduction Cell Motility Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Movement Of Cell Or Subcellular Component Wound Healing	Vitamin Metabolic Process Vitamin D Metabolic Process Steroid Metabolic Process Vitamin Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Retina Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Platelet Degranulation Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Histone H4-K16 Acetylation Blood Coagulation Hemostasis Negative Regulation Of Signal Transduction Response To Stress Negative Regulation Of T Cell Activation Response To Steroid Hormone Negative Regulation Of Signaling Negative Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Tumor Necrosis Factor Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Histone H3-K9 Acetylation Glucosylceramide Catabolic Process Maintenance Of Mitochondrion Location Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Small Molecule Metabolic Process Lipid Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor Regulation Of Body Fluid Levels Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Mononuclear Cell Migration Response To Silicon Dioxide Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Response To Organic Substance Wound Healing Response To Stimulus Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Mononuclear Cell Migration Response To Glucocorticoid Negative Regulation Of Leukocyte Activation
Tagcloud ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin
Tagcloud (Difference) ?		32dcl3 32p antisera eliminated engagement fusion fyn gst hck immunoprecipitated immunoprecipitates implying lyn lysate lzip nb2 nonphosphorylated p85 phosphatidylinositol phosphorylate phosphoserine phosphothreonine phosphotyrosine proline sh2 sh3 thymoma tyr731 yeam	accordingly advocate amn amnionless b12 coexpressed coreceptor correct critically cubilin endocytosis extremely glomerular ileum interdependency internalization lacks localize lrp2 malabsorption megalin mutually proteinuria suffer surprisingly transmembrane tubules ultrafiltrate vitamin
Tagcloud (Intersection) ?