CBL and PTPN22

  • Number of citations of the paper that reports this interaction (PMID 10068674)
  • 55
  • Data Source:
  • HPRD (in vivo, in vitro)

CBL

PTPN22

Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 9 interactors: CBL CD247 CD3E CSK GRB2 LCK PRKCD VAV1 ZAP70
Entrez ID 867 26191
HPRD ID 01320 06100
Ensembl ID ENSG00000110395 ENSG00000134242
Uniprot IDs P22681 B4DZW8 Q9Y2R2
PDB IDs 1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL 2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
aitd  antigens  autoimmunity  breakdown  cd28  cd40  ctla4  develops  discrepancy  fcrl3  happen  hashimoto  humoral  hyperthyroidism  hypothyroidism  il2ra  immunogenicity  immunoregulatory  infiltrating  insults  iodine  multifactorial  parity  preponderance  thymus  thyroglobulin  thyroid  thyrotropin  wrong 
Tagcloud (Difference) ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
aitd  antigens  autoimmunity  breakdown  cd28  cd40  ctla4  develops  discrepancy  fcrl3  happen  hashimoto  humoral  hyperthyroidism  hypothyroidism  il2ra  immunogenicity  immunoregulatory  infiltrating  insults  iodine  multifactorial  parity  preponderance  thymus  thyroglobulin  thyroid  thyrotropin  wrong 
Tagcloud (Intersection) ?