TRAF4 and SMURF2

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (two hybrid)

		TRAF4	SMURF2
Gene Name		TNF receptor-associated factor 4	SMAD specific E3 ubiquitin protein ligase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Tight Junction Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding WW Domain Binding	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Protein Ubiquitination Respiratory Tube Development Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Protein Homodimerization Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		69 interactors: ALKBH4 ARNT2 BAHD1 BANP BCKDK BCL6B BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FBXL18 FTH1 GORASP2 GPRASP1 HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGED1 MAP3K4 MRPL28 NCF1 NGFR NGFRAP1 NOS1AP NPAS2 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581	79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44
Entrez ID		9618	64750
HPRD ID		03915	06901
Ensembl ID		ENSG00000076604
Uniprot IDs		Q9BUZ4	Q96DE7 Q9HAU4
PDB IDs		2EOD 2YUC 4M4E	1ZVD 2DJY 2JQZ 2KXQ 2LTZ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of Signaling Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Response To Growth Factor Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cellular Protein Modification Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Innate Immune Response Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Programmed Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Response To Cytokine Cellular Protein Catabolic Process Cell Death Death Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development
Tagcloud ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected	autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin
Tagcloud (Difference) ?		bcr cart cd40 cd54 cd95 ciap2 define dr3 driven effector engagement fas icam linking mapk mapkapk minimal p38 permeable perturbed potentiating requirement responsive sb203580 selectively stimulates tonsillar traf1 unaffected	autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin
Tagcloud (Intersection) ?