CBL and LRIG1

  • Number of citations of the paper that reports this interaction (PMID 15282549)
  • 44

CBL

LRIG1

Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase leucine-rich repeats and immunoglobulin-like domains 1
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065)
  • Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065)
  • Carotid intima media thickness ( 21909108)
  • Renal function-related traits (BUN) ( 22797727)
  • Ventricular conduction ( 21076409)
Protein-Protein Interactions 114 interactors: ABL1 ASAP1 AXL BCR BLK BLNK BTK CAPN1 CD19 CD2AP CD38 CD40 CD5 CDKL2 CRK CRKL CSF1R CTNNB1 CUBN EGFR EIF5B EPHA2 EPHB6 EPOR ERBB2 F2RL1 FGR FLOT1 FLT3 FNBP1 FRS2 FYB FYN GIF GRB2 HCK IGF1R INPPL1 INSR ITCH ITK ITSN2 KDR KHDRBS1 KIT KRT18 LAT LAT2 LCK LCP2 LRIG1 LTK LYN MAPK8 MET MYH9 MYO1C NCK1 NOTCH1 OSTF1 PDGFRA PDGFRB PIK3R1 PIK3R2 PLCG1 PRKCA PRKCQ PTK2B PTPN11 PTPN22 PTPN6 RET SCN5A SH2B2 SH3KBP1 SHC1 SLA SLA2 SORBS1 SORBS2 SPRY2 SRC STAP2 STAT5A STAT5B SYK TCN1 TCN2 TGFBR2 TNFRSF11A TNS4 TRAF4 TRAF6 TRIM8 TYK2 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2G2 UBE2L3 UBE2M USP21 VAV1 VAV2 YES1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 1 interactors: CBL
Entrez ID 867 26018
HPRD ID 01320 10057
Ensembl ID ENSG00000110395 ENSG00000144749
Uniprot IDs P22681 Q96JA1
PDB IDs 1B47 1FBV 1YVH 2CBL 2JUJ 2K4D 2OO9 2Y1M 2Y1N 3BUM 3BUN 3BUO 3BUW 3BUX 3OB1 3OB2 3PLF 4A49 4A4B 4A4C 4GPL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
adjunct  biopsies  cadherin  cervical  cin  ck10  contraceptive  correlates  epithelium  estradiol  favorable  habits  hormonal  hormones  influences  intraepithelial  invasive  lrig2  lrig3  menopausal  neoplasia  p16  precancerous  progestogenic  retinoblastoma  smoking  stained  suppressors 
Tagcloud (Difference) ?
32dcl3  32p  antisera  eliminated  engagement  fusion  fyn  gst  hck  immunoprecipitated  immunoprecipitates  implying  lyn  lysate  lzip  nb2  nonphosphorylated  p85  phosphatidylinositol  phosphorylate  phosphoserine  phosphothreonine  phosphotyrosine  proline  sh2  sh3  thymoma  tyr731  yeam 
adjunct  biopsies  cadherin  cervical  cin  ck10  contraceptive  correlates  epithelium  estradiol  favorable  habits  hormonal  hormones  influences  intraepithelial  invasive  lrig2  lrig3  menopausal  neoplasia  p16  precancerous  progestogenic  retinoblastoma  smoking  stained  suppressors 
Tagcloud (Intersection) ?