SH3KBP1 and CAPZA1

Number of citations of the paper that reports this interaction (PMID 12690097)
27

Data Source:
HPRD (in vitro)

		SH3KBP1	CAPZA1
Gene Name		SH3-domain kinase binding protein 1	capping protein (actin filament) muscle Z-line, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Vesicular Exosome WASH Complex
	Molecular Function	Protein Binding SH3 Domain Binding	Actin Binding Protein Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Protein Complex Assembly Movement Of Cell Or Subcellular Component Blood Coagulation Innate Immune Response Barbed-end Actin Filament Capping
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Factors involved in megakaryocyte development and platelet production Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs
Diseases
GWAS			Blood pressure ( 21572416)
Protein-Protein Interactions		45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219	7 interactors: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5
Entrez ID		30011	829
HPRD ID		02301	03347
Ensembl ID		ENSG00000147010	ENSG00000116489
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	P52907
PDB IDs		2BZ8 2K6D 2K9G 2O2O 2YDL	1MQ1 1MWN
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response	Midbrain Development Substantia Nigra Development 'de Novo' Posttranslational Protein Folding Central Nervous System Development 'de Novo' Protein Folding Neural Nucleus Development Cellular Response To Stimulus Nervous System Development Cell Projection Organization Locomotion Negative Regulation Of Fibril Organization Axonogenesis Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Neuron Projection Morphogenesis Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Fibril Organization Cell Morphogenesis Involved In Differentiation Regulation Of Cell Shape Signaling Brain Development Negative Regulation Of Skeletal Muscle Cell Differentiation Cell Communication Head Development Regulation Of Cellular Component Organization Neuron Projection Development Clathrin Coat Disassembly Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Neuron Development System Development Cell Morphogenesis Protein Folding Anatomical Structure Morphogenesis Response To Methylmercury Neuron Differentiation Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Axon Guidance Anatomical Structure Development Regulation Of Skeletal Muscle Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Refolding
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9	cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6
Tagcloud (Intersection) ?