SH3KBP1 and CAPZA1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		SH3KBP1	CAPZA1
Description		SH3 domain containing kinase binding protein 1	capping actin protein of muscle Z-line subunit alpha 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Cortical Cytoskeleton Extracellular Exosome WASH Complex
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Actin Cytoskeleton Organization Cell Junction Assembly Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Diastolic blood pressure ( 26390057 27618452 27841878 28739976 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29785010 29617998) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30487518 28739976 27841878 27618452) Total cholesterol levels ( 30275531)
Interacting Genes		59 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	7 interacting genes: ACTB CD2AP CEBPA S100A1 S100B SH3KBP1 UCHL5
Entrez ID		30011	829
HPRD ID		02301	03347
Ensembl ID		ENSG00000147010	ENSG00000116489
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	P52907
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	1MQ1 1MWN 7T5Q 8F8Q
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Regulation Of Multicellular Organismal Process S100 Protein Binding Cell-cell Junction Maintenance Of Blood-brain Barrier Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Substantia Nigra Development Protein-containing Complex Tau Protein Binding Positive Regulation Of Multicellular Organismal Process Identical Protein Binding Positive Regulation Of Immune System Process Neural Nucleus Development Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Calcium-dependent Protein Binding Actin Filament Structural Constituent Of Cytoskeleton Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Response To Vitamin B2 Liver Development C/EBP Complex Ruffle SH3 Domain Binding Positive Regulation Of Developmental Process Memory Developmental Cell Growth Positive Regulation Of DNA Repair Nuclear Matrix Transporter Regulator Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Glucocorticoid Regulation Of Cell Shape Developmental Growth Involved In Morphogenesis Regulation Of Transepithelial Transport Axonogenesis Regulation Of Cell Activation White Fat Cell Proliferation Response To Corticosteroid Response To Hormone System Process Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Cell Differentiation Protein Localization To Adherens Junction Dense Body
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