SH3KBP1 and BLNK

Number of citations of the paper that reports this interaction (PubMedID 21822214)
60

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		SH3KBP1	BLNK
Description		SH3 domain containing kinase binding protein 1	B cell linker
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Lipid Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Molecular Condensate Scaffold Activity Protein Tyrosine Kinase Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Inflammatory Response Humoral Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Activation B Cell Receptor Signaling Pathway
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Regulation of signaling by CBL Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Platelet count ( 32888494)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		59 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		30011	29760
HPRD ID		02301	05153
Ensembl ID		ENSG00000147010	ENSG00000095585
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	Q2MD54 Q2MD59 Q8WV28
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	6YLU
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Leukocyte Activation Lymphocyte Activation B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of MAPK Cascade Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell-cell Junction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling T Cell Activation Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Positive Regulation Of Multicellular Organismal Process Leukocyte Proliferation ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Receptor Tyrosine Kinase Binding Cell Population Proliferation Plasma Membrane Negative Regulation Of Immune System Process
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