SH3KBP1 and ARHGAP27

Number of citations of the paper that reports this interaction (PMID 15147912)
4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SH3KBP1	ARHGAP27
Gene Name		SH3-domain kinase binding protein 1	Rho GTPase activating protein 27
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Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Intracellular Cytoplasm Membrane
	Molecular Function	Protein Binding SH3 Domain Binding	SH3 Domain Binding Rac GTPase Activator Activity
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Receptor-mediated Endocytosis Signal Transduction Positive Regulation Of Rac GTPase Activity Positive Regulation Of Cdc42 GTPase Activity
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219	3 interactors: CDC42 RAC1 SH3KBP1
Entrez ID		30011	201176
HPRD ID		02301	12477
Ensembl ID		ENSG00000147010	ENSG00000159314
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	E9PNT2 Q6ZUM4 Q8N2Y9
PDB IDs		2BZ8 2K6D 2K9G 2O2O 2YDL	3PP2
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response	Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Endocytosis Positive Regulation Of DNA Replication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Regulation Of ERBB Signaling Pathway Cell Migration Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion Regulation Of DNA Replication Epidermal Cell Differentiation Cytoskeleton Organization Positive Regulation Of DNA Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation ERBB Signaling Pathway Locomotion Regulation Of Cell-substrate Adhesion Epithelial Cell Development Positive Regulation Of T Cell Activation Cell-cell Junction Organization Vesicle-mediated Transport Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Movement Of Cell Or Subcellular Component Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Actin Filament Branching Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Phagocytosis Epidermis Development Fc Receptor Signaling Pathway
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?