SH3KBP1 and ARAP3

Number of citations of the paper that reports this interaction (PubMedID 31980649)
68

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		SH3KBP1	ARAP3
Description		SH3 domain containing kinase binding protein 1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		59 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	11 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 SNCA TNKS2
Entrez ID		30011	64411
HPRD ID		02301	09441
Ensembl ID		ENSG00000147010	ENSG00000120318
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	2KG5 2LNW 5JCP 5JD0 7A9B 7YIR 7YIS
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Cell Death ERK1 And ERK2 Cascade Apoptotic Process SH3 Domain Binding Vesicle-mediated Transport Actin Filament Organization Establishment Of Organelle Localization Cell Projection Programmed Cell Death Regulation Of Immune System Process Supramolecular Fiber Organization MAPK Cascade Response To Desipramine Negative Regulation Of Norepinephrine Uptake Protein Complex Oligomerization Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Destabilization Protein-containing Complex Cell-cell Junction DGTPase Activity DGTP Binding Triphosphoric Monoester Hydrolase Activity Deoxynucleoside Triphosphate Hydrolase Activity Plasma Membrane Bounded Cell Projection Assembly Regulation Of Amide Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Neuron Projection DATP Catabolic Process DGTP Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Projection Assembly Actin Binding Protein Tetramerization Cellular Component Assembly Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Secretion By Cell Anchoring Junction DGTP Metabolic Process Regulated Exocytosis Regulation Of Immune Response Endocytosis Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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