SH3KBP1 and BCAR1

Number of citations of the paper that reports this interaction (PubMedID 12618476)
0

Data Source:
HPRD (in vivo)

		SH3KBP1	BCAR1
Description		SH3 domain containing kinase binding protein 1	BCAR1 scaffold protein, Cas family member
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cell Projection Anchoring Junction
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 25086665 29422604) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		59 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EEIG1 EFS ESR1 FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ
Entrez ID		30011	9564
HPRD ID		02301	04248
Ensembl ID		ENSG00000147010	ENSG00000050820
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	B3KWE2 P56945
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Cell Migration Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Signal Transduction Cell Motility Regulation Of Cell-substrate Adhesion Ephrin Receptor Signaling Pathway Anchoring Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Regulation Of Immune System Process Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Regulation Of Cell Motility Antigen Receptor-mediated Signaling Pathway SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Migration Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell-matrix Adhesion Intracellular Signal Transduction Cytosol Regulation Of Cytoskeleton Organization Cytoplasm Regulation Of Signal Transduction Cell Adhesion Cell-cell Junction Regulation Of Cell Junction Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?