SH3KBP1 and SYNJ1

Number of citations of the paper that reports this interaction (PubMedID 19531213)
92

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SH3KBP1	SYNJ1
Description		SH3 domain containing kinase binding protein 1	synaptojanin 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Endocytic Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Anchoring Junction Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse
	Molecular Function	Protein Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		59 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GPRASP3 GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	30 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2
Entrez ID		30011	8867
HPRD ID		02301	09182
Ensembl ID		ENSG00000147010	ENSG00000159082
Uniprot IDs		A0A8V8TNL0 A0A8V8TNT5 A0A8V8TNW8 A0A8V8TP27 A0A8V8TP33 A0A8V8TP40 A0A8V8TP63 A0A8V8TP69 A0A8V8TPM1 A0A8V8TQF6 A0A8V8TQU1 B7Z6E8 Q5JPT2 Q5JPT6 Q96B97	A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cytosol Phosphotyrosine Residue Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Cytoplasm Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Endocytosis Regulation Of Actin Filament Organization Immune Response-activating Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin Receptor Signaling Pathway Protein Binding Natural Killer Cell Mediated Cytotoxicity Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Cadherin Binding Activation Of Immune Response Natural Killer Cell Mediated Immunity Regulation Of Apoptotic Process Signal Transduction Protein Kinase Binding Regulation Protein Catabolic Process At Postsynapse B Cell Receptor Signaling Pathway Positive Regulation Of Membrane Tubulation Vesicle-mediated Transport Receptor Catabolic Process Regulation Of Signal Transduction Import Into Cell Establishment Of Localization In Cell Regulation Of Supramolecular Fiber Organization Receptor Tyrosine Kinase Binding Positive Regulation Of Cellular Component Biogenesis Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Viral Budding	Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery
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