MYBPC1 and ACO1

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		MYBPC1	ACO1
Name		myosin binding protein C1	aconitase 1
Structure
GO Annotations	Cellular Component	Cytosol Myofibril M Band Myosin Filament	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Lyase Activity Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Cell Adhesion Sarcomere Organization	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation NADPH Regeneration Intracellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Regulation Of Gene Expression Negative Regulation Of Translation Intestinal Absorption
Pathways		Striated Muscle Contraction	NADPH regeneration Iron uptake and transport
GWAS		Lung function (FEV1) ( 24023788 ) Memory decline ( 31985465 )	Asthma ( 22561531 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) Inflammatory skin disease ( 25574825 ) Lateral ventricle temporal horn volume ( 31530798 ) Motion sickness ( 25628336 ) Red blood cell count ( 27863252 32888494 ) Smoking status (ever vs never smokers) ( 30643258 )
Interacting Genes		27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN	10 interacting genes: APP CCDC69 CDC42 CLTC DSCAM FTL MYBPC1 NEB PXN RNF10
Entrez ID		4604	48
HPRD ID		01185	00013
Ensembl ID		ENSG00000196091	ENSG00000122729
Uniprot IDs		A8KAB1 B3KPP3 Q00872	P21399 Q9HBB2 V9HWB7
PDB IDs		1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM	2B3X 2B3Y
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response	Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Low-density Lipoprotein Particle Receptor Binding Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Recognition Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Spindle Spindle Midzone Positive Regulation Of Actin Filament Bundle Assembly Iron Ion Transport Myofibril Structural Constituent Of Muscle Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Cellular Component Assembly Clathrin-coated Pit Cell Adhesion Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process GBD Domain Binding Storage Vacuole Cytoskeleton Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Ferritin Complex Regulation Of Supramolecular Fiber Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Recognition Lysosome Dendrite Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Endocytosis