MYBPC1 and NCF1

Number of citations of the paper that reports this interaction (PubMedID 16052631)
0

Data Source:
BioGRID (two hybrid)

		MYBPC1	NCF1
Description		myosin binding protein C1	neutrophil cytosolic factor 1
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GO Annotations	Cellular Component	Cytosol Myofibril M Band Myosin Filament	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Cell Adhesion Sarcomere Organization	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process
Pathways		Striated Muscle Contraction	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Lung function (FEV1) ( 24023788) Memory decline ( 31985465)	Systemic lupus erythematosus ( 33493351)
Interacting Genes		27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN	29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		4604	653361
HPRD ID		01185
Ensembl ID		ENSG00000196091	ENSG00000158517
Uniprot IDs		A8KAB1 B3KPP3 Q00872	P14598
PDB IDs		1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development
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