MYBPC1 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 16407297)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MYBPC1	FHL2
Description		myosin binding protein C1	four and a half LIM domains 2
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GO Annotations	Cellular Component	Cytosol Myofibril M Band Myosin Filament	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	Cell Adhesion Sarcomere Organization	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Striated Muscle Contraction	PPARA activates gene expression
Drugs
Diseases
GWAS		Lung function (FEV1) ( 24023788) Memory decline ( 31985465)	Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)
Interacting Genes		27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN	175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9
Entrez ID		4604	2274
HPRD ID		01185	04026
Ensembl ID		ENSG00000196091	ENSG00000115641
Uniprot IDs		A8KAB1 B3KPP3 Q00872	Q14192 Q2XQU9 Q6I9R8
PDB IDs		1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex
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