FAM161A and TRIM37

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FAM161A	TRIM37
Gene Name		family with sequence similarity 161, member A	tripartite motif containing 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Photoreceptor Connecting Cilium Ciliary Basal Body	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Visual Perception Cilium Assembly Response To Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		63 interactors: BEND3 BEND5 BRCA1 CADPS CALCOCO1 CALCOCO2 CARD9 CCDC102B CCDC136 CCDC155 CCDC33 CCDC57 CDR2 CEP44 CEP57L1 CEP63 CEP70 DHX32 DOCK8 EHMT2 FAM9B FSD2 HMBOX1 IKZF1 KIAA0753 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 LZTS2 MCM6 MDFI MID2 MIPOL1 MTUS2 NECAB2 NINL NUTM1 PDE4DIP PHC2 PNMA2 POC5 PPFIA1 PPM1F RINT1 RUNDC3A SPERT SSX2IP STX11 SYCE1 TFIP11 TMCC2 TNIP1 TRAF1 TRIM15 TRIM37 TRIM54 TSGA10 TXLNB ZBTB1 ZBTB14 ZBTB43 ZBTB8A	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		84140	4591
HPRD ID		18996	05463
Ensembl ID		ENSG00000170264	ENSG00000108395
Uniprot IDs		Q3B820	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?		Cell Cycle Negative Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Centriole Replication Cell Cycle Process Negative Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Synapsis Homologous Chromosome Segregation Negative Regulation Of Cytoskeleton Organization Regulation Of Centriole Replication Leukocyte Cell-cell Adhesion Cellular Component Assembly Negative Regulation Of Viral Process Negative Regulation Of Viral Release From Host Cell Meiotic Chromosome Segregation Negative Regulation Of Centrosome Duplication Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Biosynthetic Process Centrosome Organization Chromosome Segregation Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Viral Release From Host Cell Regulation Of Nitrogen Compound Metabolic Process Synaptonemal Complex Assembly Microtubule Cytoskeleton Organization Meiosis I Microtubule Organizing Center Organization Synaptonemal Complex Organization Neurotransmitter Secretion Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Chromosome Organization Regulation Of Cytoskeleton Organization Microtubule-based Process Regulation Of Neurotransmitter Levels Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
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