FAM161A and PPFIA1

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		FAM161A	PPFIA1
Description		FAM161 centrosomal protein A	PPFI scaffold protein A1
Image		No pdb structure
GO Annotations	Cellular Component	Astral Microtubule Photoreceptor Inner Segment Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Spindle Microtubule Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Mitotic Spindle Mitotic Spindle Pole	Cytoplasm Cytosol Focal Adhesion Cell Cortex Axon Dendrite Protein-containing Complex Presynaptic Active Zone Spine Apparatus Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding	Protein Binding
	Biological Process	Visual Perception Cell Projection Organization Cilium Organization Cilium Assembly	Cell-matrix Adhesion Signal Transduction Cortical Microtubule Organization Synapse Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Atrial fibrillation ( 29892015) Erectile dysfunction ( 30583798) Systemic lupus erythematosus ( 28714469)	Coronary artery disease ( 29212778) Lymphocyte count ( 32888494)
Interacting Genes		139 interacting genes: AQP1 AXIN2 BACH2 BEGAIN BEND3 BEND5 BICD2 BRCA1 CADPS CALCOCO1 CALCOCO2 CARD9 CBY2 CCDC102B CCDC125 CCDC13 CCDC136 CCDC185 CCDC33 CCDC57 CCDC88B CCNC CCNDBP1 CDR2 CDR2L CEP44 CEP57L1 CEP63 CEP70 CEP72 CTNNA3 DHX32 DOCK8 DRC4 DVL2 EHMT2 EVI5 FAM9B FSD2 FXR1 GOLGA2 GOLGA6L9 GPBP1 GPRASP3 GRIPAP1 HEXIM2 HMBOX1 HOOK1 HOOK2 IKZF1 INO80E JRK KANK2 KASH5 KAT5 KDM1A KIAA0753 KIAA1328 KIFC3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LMNA LURAP1L LZTS1 LZTS2 MAGEA11 MCC MCM6 MDFI MID2 MIPOL1 MKRN1 MTCL2 MTUS2 NECAB2 NINL NUTM1 OSBPL3 PDE4DIP PHC2 PIBF1 PICK1 PLEKHG4 PNMA1 PNMA2 POC5 PPFIA1 PPM1F PPP2R3C PRKAR1B QARS1 RINT1 ROPN1 RUBCN RUNDC3A SCNM1 SMARCD1 SSX2IP STX11 SYCE1 TAX1BP1 TBC1D1 TFIP11 TMCC2 TNIP1 TNIP3 TRAF1 TRAF2 TRIB3 TRIM15 TRIM27 TRIM37 TRIM41 TRIM54 TRIM69 TSGA10 TXLNB VIM VPS52 ZBTB1 ZBTB14 ZBTB43 ZBTB8A ZIM2 ZNF24 ZNF250 ZNF276 ZNF426 ZNF526 ZNF792 ZRANB1 ZSCAN12	32 interacting genes: AGTPBP1 CAGE1 CAST CCNH CDK18 CEP70 CNKSR1 DRC4 DTNB DYNC1I2 ELOA ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5A PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA USP7 YWHAG
Entrez ID		84140	8500
HPRD ID		18996	11451
Ensembl ID		ENSG00000170264	ENSG00000131626
Uniprot IDs		Q3B820	A0AAG2UWZ2 B3KVS8 Q13136
PDB IDs			1N7F
Enriched GO Terms of Interacting Partners?		Protein Binding Microtubule-based Process Identical Protein Binding Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Cytoskeleton Intermediate Filament Centriole Replication Cytoplasm Centrosome Cycle Centriole Assembly Cytoskeleton Organization Microtubule Binding Cytoplasmic Microtubule Organization Response To Muramyl Dipeptide Microtubule Organelle Organization Negative Regulation Of RNA Metabolic Process Cellular Response To Muramyl Dipeptide Dynein Light Intermediate Chain Binding Zinc Ion Binding Regulation Of Organelle Organization Membraneless Organelle Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centriolar Satellite Keratin Filament Cytosol Microtubule Organizing Center Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Organelle Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Suppression Of Viral Release By Host Centriole Negative Regulation Of Fatty Acid Biosynthetic Process Transcription Coactivator Activity Nuclear Pore Localization FHF Complex Ubiquitin Protein Ligase Activity Protein Localization To Cytoskeleton Nucleus	Synapse Organization Presynaptic Active Zone Cell Junction Organization Maintenance Of Synapse Structure Presynaptic Active Zone Organization Presynaptic Active Zone Cytoplasmic Component Cell Junction Maintenance Transmembrane Receptor Protein Tyrosine Phosphatase Activity Synapse Presynaptic Membrane Cellular Component Maintenance Synaptic Membrane Adhesion Gamma-tubulin Binding Protein Tyrosine Phosphatase Activity Modulation Of Chemical Synaptic Transmission Cell Projection Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Presynapse Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Postsynaptic Density Cytosol Phosphoprotein Phosphatase Activity Regulation Of Dendritic Spine Development Growth Cone Maintenance Of Postsynaptic Specialization Structure Cytoplasm Centrosome Inhibitory Synapse Protein Phosphatase Type 2A Complex Regulation Of Postsynaptic Density Assembly Protein Phosphatase Activator Activity Heparan Sulfate Proteoglycan Binding Protein Dephosphorylation Presynapse Organization Glutamatergic Synapse Postsynaptic Density Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Postsynaptic Specialization Organization Regulation Of Axon Regeneration Negative Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Neuron Projection Regeneration Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Plasma Membrane Raft Distribution Chondroitin Sulfate Proteoglycan Binding Slow-twitch Skeletal Muscle Fiber Contraction Structural Constituent Of Presynapse
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