FAM161A and KANK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM161A	KANK2
Description		FAM161 centrosomal protein A	KN motif and ankyrin repeat domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Astral Microtubule Photoreceptor Inner Segment Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Spindle Microtubule Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Mitotic Spindle Mitotic Spindle Pole	Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding	Protein Binding
	Biological Process	Visual Perception Cell Projection Organization Cilium Organization Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Podocyte Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Atrial fibrillation ( 29892015) Erectile dysfunction ( 30583798) Systemic lupus erythematosus ( 28714469)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean spheric corpuscular volume ( 32888494) Non-HDL cholesterol levels ( 32902719) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 32203549)
Interacting Genes		139 interacting genes: AQP1 AXIN2 BACH2 BEGAIN BEND3 BEND5 BICD2 BRCA1 CADPS CALCOCO1 CALCOCO2 CARD9 CBY2 CCDC102B CCDC125 CCDC13 CCDC136 CCDC185 CCDC33 CCDC57 CCDC88B CCNC CCNDBP1 CDR2 CDR2L CEP44 CEP57L1 CEP63 CEP70 CEP72 CTNNA3 DHX32 DOCK8 DRC4 DVL2 EHMT2 EVI5 FAM9B FSD2 FXR1 GOLGA2 GOLGA6L9 GPBP1 GPRASP3 GRIPAP1 HEXIM2 HMBOX1 HOOK1 HOOK2 IKZF1 INO80E JRK KANK2 KASH5 KAT5 KDM1A KIAA0753 KIAA1328 KIFC3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LMNA LURAP1L LZTS1 LZTS2 MAGEA11 MCC MCM6 MDFI MID2 MIPOL1 MKRN1 MTCL2 MTUS2 NECAB2 NINL NUTM1 OSBPL3 PDE4DIP PHC2 PIBF1 PICK1 PLEKHG4 PNMA1 PNMA2 POC5 PPFIA1 PPM1F PPP2R3C PRKAR1B QARS1 RINT1 ROPN1 RUBCN RUNDC3A SCNM1 SMARCD1 SSX2IP STX11 SYCE1 TAX1BP1 TBC1D1 TFIP11 TMCC2 TNIP1 TNIP3 TRAF1 TRAF2 TRIB3 TRIM15 TRIM27 TRIM37 TRIM41 TRIM54 TRIM69 TSGA10 TXLNB VIM VPS52 ZBTB1 ZBTB14 ZBTB43 ZBTB8A ZIM2 ZNF24 ZNF250 ZNF276 ZNF426 ZNF526 ZNF792 ZRANB1 ZSCAN12	187 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CFAP68 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT31 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NRIP1 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 UBC USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1
Entrez ID		84140	25959
HPRD ID		18996	12463
Ensembl ID		ENSG00000170264	ENSG00000197256
Uniprot IDs		Q3B820	Q63ZY3
PDB IDs			4HBD 5YBV 6TMD
Enriched GO Terms of Interacting Partners?		Protein Binding Microtubule-based Process Identical Protein Binding Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Cytoskeleton Intermediate Filament Centriole Replication Cytoplasm Centrosome Cycle Centriole Assembly Cytoskeleton Organization Microtubule Binding Cytoplasmic Microtubule Organization Response To Muramyl Dipeptide Microtubule Organelle Organization Negative Regulation Of RNA Metabolic Process Cellular Response To Muramyl Dipeptide Dynein Light Intermediate Chain Binding Zinc Ion Binding Regulation Of Organelle Organization Membraneless Organelle Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centriolar Satellite Keratin Filament Cytosol Microtubule Organizing Center Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Organelle Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Suppression Of Viral Release By Host Centriole Negative Regulation Of Fatty Acid Biosynthetic Process Transcription Coactivator Activity Nuclear Pore Localization FHF Complex Ubiquitin Protein Ligase Activity Protein Localization To Cytoskeleton Nucleus	Protein Binding Identical Protein Binding Nucleus Structural Constituent Of Skin Epidermis
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