RNF168 and HIST2H2AC

Number of citations of the paper that reports this interaction (PMID 22980979)
38

Data Source:
BioGRID (enzymatic study)

		RNF168	HIST2H2AC
Gene Name		ring finger protein 168, E3 ubiquitin protein ligase	histone cluster 2, H2ac
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Site Of Double-strand Break	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Nucleosome Binding Histone Binding Ubiquitin Binding K63-linked Polyubiquitin Binding	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Biological_process
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		12 interactors: H2AFX HIST2H2AC JMJD1C KDM4A KIAA0368 LAPTM5 RABGEF1 RNF11 UBC UBE2D3 UBE2E1 UBE2G2	65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46
Entrez ID		165918	8338
HPRD ID		08190	09107
Ensembl ID		ENSG00000163961	ENSG00000184260
Uniprot IDs		Q8IYW5	Q16777
PDB IDs		3L11 4GB0
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Cellular Macromolecule Catabolic Process Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Catabolic Process Negative Regulation Of Cytokine Production ER-associated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Checkpoint Protein Monoubiquitination Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromatin Organization Cellular Protein Modification Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Kit Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Chromosome Organization Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Intersection) ?