RNF168 and RABGEF1

Number of citations of the paper that reports this interaction (PubMedID 16499958)
0

Data Source:
HPRD (in vitro)

		RNF168	RABGEF1
Description		ring finger protein 168	RAB guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break Catalytic Complex	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Radiation Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)	Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)
Interacting Genes		40 interacting genes: ALAS1 ATF6 DGCR8 DHX9 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC21 H2BC3 HDAC6 JMJD1C KDM1A KDM4A KMT5A LAPTM5 MACROH2A1 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2G2 UBE2L3 UBE2N USP7 WBP2	49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C
Entrez ID		165918	27342
HPRD ID		08190	11477
Ensembl ID		ENSG00000163961	ENSG00000154710
Uniprot IDs		Q8IYW5	A8K3R3 B3KMF1 Q9UJ41
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU	1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Chromatin Organization Protein Ubiquitination Chromatin Remodeling Nucleus Protein Modification Process Structural Constituent Of Chromatin Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Nucleosome Proteolysis Nucleoplasm Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Enzyme Binding Cellular Response To Stress Ubiquitin Protein Ligase Binding Chromosome Negative Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of Metabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Heterochromatin Formation Protein K63-linked Ubiquitination Protein-containing Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Chromatin DNA Binding Transferase Activity	Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell
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