RNF168 and DGCR8

Number of citations of the paper that reports this interaction (PubMedID 34188037)
86

Data Source:
BioGRID (pull down)

		RNF168	DGCR8
Description		ring finger protein 168	DGCR8 microprocessor complex subunit
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break Catalytic Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Nuclear Body Site Of Double-strand Break Microprocessor Complex Glutamatergic Synapse
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity	RNA Binding Double-stranded RNA Binding Protein Binding Heme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding Protein-RNA Adaptor Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Radiation Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling	DNA Damage Response Primary MiRNA Processing Regulation Of Stem Cell Proliferation Positive Regulation Of Pre-miRNA Processing
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)	Adult body size ( 32376654) Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)
Interacting Genes		40 interacting genes: ALAS1 ATF6 DGCR8 DHX9 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC21 H2BC3 HDAC6 JMJD1C KDM1A KDM4A KMT5A LAPTM5 MACROH2A1 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2G2 UBE2L3 UBE2N USP7 WBP2	6 interacting genes: APP DROSHA MEOX2 RNF10 RNF168 USP51
Entrez ID		165918	54487
HPRD ID		08190	09913
Ensembl ID		ENSG00000163961	ENSG00000128191
Uniprot IDs		Q8IYW5	Q8WYQ5
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU	1X47 2YT4 3LE4 5B16 6LXD 6LXE 6V5B 6V5C 7CNC 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Chromatin Organization Protein Ubiquitination Chromatin Remodeling Nucleus Protein Modification Process Structural Constituent Of Chromatin Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Nucleosome Proteolysis Nucleoplasm Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Enzyme Binding Cellular Response To Stress Ubiquitin Protein Ligase Binding Chromosome Negative Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of Metabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Heterochromatin Formation Protein K63-linked Ubiquitination Protein-containing Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Chromatin DNA Binding Transferase Activity	Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Microprocessor Complex Ribonuclease III Activity DNA Repair-dependent Chromatin Remodeling Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Metabolic Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Somite Specification Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane
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