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RNF168
Gene Name
ring finger protein 168, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Site Of Double-strand Break
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Nucleosome Binding
Histone Binding
Ubiquitin Binding
K63-linked Polyubiquitin Binding
Biological Process
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Response To Ionizing Radiation
Protein Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2A Monoubiquitination
Interstrand Cross-link Repair
Histone H2A-K13 Ubiquitination
Histone H2A-K15 Ubiquitination
Isotype Switching
Positive Regulation Of DNA Repair
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS
Fat distribution (HIV) (
21897333
)
Protein-protein Interactions
12 interactors:
H2AFX
HIST2H2AC
JMJD1C
KDM4A
KIAA0368
LAPTM5
RABGEF1
RNF11
UBC
UBE2D3
UBE2E1
UBE2G2
Entrez ID
165918
HPRD ID
08190
Ensembl ID
ENSG00000163961
Uniprot IDs
Q8IYW5
PDB IDs
3L11
4GB0
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Macromolecule Catabolic Process
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Catabolic Process
Negative Regulation Of Cytokine Production
ER-associated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle Checkpoint
Protein Monoubiquitination
Negative Regulation Of Type I Interferon Production
Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Chromatin Organization
Cellular Protein Modification Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Kit Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Negative Regulation Of Protein Ubiquitination
Chromosome Organization
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Protein Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Tagcloud
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53bp1
atm
brca1
cdk1
comparatively
coordinates
cytosol
ddr
enables
exit
flanking
genotoxic
h2a
homologous
impairs
interphase
joining
kinetochores
ligases
localize
mitosis
mitotic
plk1
properly
recombination
rnf8
s1618
spatiotemporally
ubiquitinated