RNF168 and RNF11

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RNF168	RNF11
Gene Name		ring finger protein 168, E3 ubiquitin protein ligase	ring finger protein 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Early Endosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Nucleosome Binding Histone Binding Ubiquitin Binding K63-linked Polyubiquitin Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Ventricular conduction ( 21076409)
Protein-Protein Interactions		12 interactors: H2AFX HIST2H2AC JMJD1C KDM4A KIAA0368 LAPTM5 RABGEF1 RNF11 UBC UBE2D3 UBE2E1 UBE2G2	68 interactors: AKT1 ANKRD13A APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP STAMBPL1 TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		165918	26994
HPRD ID		08190	09955
Ensembl ID		ENSG00000163961	ENSG00000123091
Uniprot IDs		Q8IYW5	Q9Y3C5
PDB IDs		3L11 4GB0
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Cellular Macromolecule Catabolic Process Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Catabolic Process Negative Regulation Of Cytokine Production ER-associated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Checkpoint Protein Monoubiquitination Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Chromatin Organization Cellular Protein Modification Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Kit Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Protein Ubiquitination Chromosome Organization Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cellular Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Protein Modification Process Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Negative Regulation Of Signaling Toll-like Receptor 4 Signaling Pathway Protein K63-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Immune Response-regulating Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Intracellular Transport Cellular Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Intracellular Protein Transport Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Innate Immune Response Cellular Response To Stimulus
Tagcloud ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Difference) ?		53bp1 atm brca1 cdk1 comparatively coordinates cytosol ddr enables exit flanking genotoxic h2a homologous impairs interphase joining kinetochores ligases localize mitosis mitotic plk1 properly recombination rnf8 s1618 spatiotemporally ubiquitinated
Tagcloud (Intersection) ?