KAT5 and HMBOX1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KAT5	HMBOX1
Gene Name		K(lysine) acetyltransferase 5	homeobox containing 1
Image
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513	48 interactors: AEBP2 APP ASB7 ATP5O BYSL C20orf195 C8orf33 CARD9 CBX8 CCNG1 DAB1 DYNLL2 ENTPD2 FAM13C FAM161A FAM206A FAM74A4 FARS2 FRMD6 FXR2 KAT5 LNX1 MAGEH1 MFAP1 MORF4L1 MRPL11 MRPL28 PIP4K2B PKD1P1 PRKAA1 PRKAA2 RBMY2FP REEP6 RPL9 SAP30L SFR1 SH2D4A SNRPB2 TCEANC UBA6 UBE2Z VPS72 ZBTB24 ZMAT2 ZNF337 ZNF417 ZNF581 ZNF587
Entrez ID		10524	79618
HPRD ID		03245	07964
Ensembl ID		ENSG00000172977	ENSG00000147421
Uniprot IDs		Q92993	D3DSU2 Q6NT76
PDB IDs		2EKO 2OU2	2CUF 4J19
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process	Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Chromatin Organization Biosynthetic Process Chromatin Modification Cellular Metabolic Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Chromosome Organization Fatty Acid Homeostasis Histone Modification Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Cholesterol Metabolic Process Organelle Organization Sterol Metabolic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Translational Termination Positive Regulation Of Autophagy Neuron Recognition Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Synaptic Target Recognition Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Double-strand Break Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Histone Phosphorylation Sterol Biosynthetic Process Protein Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anion Homeostasis Translational Elongation Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Cellular Process Regulation Of RNA Metabolic Process Cerebellum Structural Organization
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	adherens aqp2 aqp3 bioinformatic collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 scnn1b scnn1g vasopressin
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	adherens aqp2 aqp3 bioinformatic collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 scnn1b scnn1g vasopressin
Tagcloud (Intersection) ?