KAT5 and TBX5

Number of citations of the paper that reports this interaction (PMID 15591049)
7

Data Source:
BioGRID (pull down)

		KAT5	TBX5
Gene Name		K(lysine) acetyltransferase 5	T-box 5
Image
Gene Ontology Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Protein Complex Binding Metal Ion Binding Androgen Receptor Binding Repressing Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Chromatin Organization Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Viral Process Histone Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Acetylation	Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Apoptotic Nuclear Changes Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of Execution Phase Of Apoptosis
Pathways		Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146)	Airflow obstruction ( 22837378) Blood pressure ( 21909110) Diastolic blood pressure ( 19430479) Electrocardiographic traits ( 20062063) Mammographic density ( 22532574) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255) Prostate cancer ( 23535732) Ventricular conduction ( 21076409) Visceral fat ( 22589738)
Protein-Protein Interactions		136 interactors: ALOX12 APBB1 APLP1 APLP2 APP AR ARIH2 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CREB1 CREBBP CRELD1 CSTF2 DLEU1 DUSP23 E2F1 EDNRA EFNA1 EP300 ESR1 ESR2 ETV6 FAM101B FAM135B FAM173A GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL1P1 GOLGA2 GSTO1 H2AFX H3F3B HABP4 HAP1 HDAC1 HDAC7 HIST1H3A HIST1H4A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMBOX1 HNRNPH3 IK IKZF3 IL9R KIAA1377 KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PHC2 PIH1D3 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RGL2 RRM1 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513	4 interactors: GATA4 KAT5 KDM6A NKX2-5
Entrez ID		10524	6910
HPRD ID		03245	03372
Ensembl ID		ENSG00000172977	ENSG00000089225
Uniprot IDs		Q92993	Q99593
PDB IDs		2EKO 2OU2	2X6U 2X6V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Positive Regulation Of Metabolic Process Mitotic Cell Cycle Chromosome Organization Anatomical Structure Development Cellular Macromolecule Biosynthetic Process System Development Tissue Development Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cell Death Apoptotic Process Death Organelle Organization Programmed Cell Death Biosynthetic Process	Positive Regulation Of Cardioblast Differentiation Canonical Wnt Signaling Pathway Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Heart Morphogenesis Atrial Septum Development Wnt Signaling Pathway Cardiac Atrium Morphogenesis Embryonic Organ Morphogenesis Cardiac Muscle Tissue Growth Epithelial Tube Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Tube Morphogenesis Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Pattern Specification Process Embryonic Organ Development Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Morphogenesis Of An Epithelium Determination Of Heart Left/right Asymmetry Heart Development Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Regulation Of Growth Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Embryonic Morphogenesis Tissue Morphogenesis Organ Growth Tube Development Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation
Tagcloud ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Difference) ?		accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat2b kat3a kat3b multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes hnf4a house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 transcripts
Tagcloud (Intersection) ?