KAT5 and SSX2IP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KAT5	SSX2IP
Description		lysine acetyltransferase 5	SSX family member 2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Chromatin Nucleosome Swr1 Complex Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol Cytoskeleton Nuclear Lumen Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Mitotic Spindle Pole	Nucleus Cytoplasm Centrosome Cytoskeleton Adherens Junction Cell Leading Edge Protein-containing Complex Centriolar Satellite Ciliary Basal Body Cell Projection Anchoring Junction
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H2A Acetyltransferase Activity Histone H2AK5 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptide Crotonyltransferase Activity Peptide Butyryltransferase Activity DNA-binding Transcription Factor Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Immune System Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Apoptotic Process DNA Damage Response Spermatid Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Triglyceride Biosynthetic Process Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Neural Tube Development Neurogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Interleukin-2 Production Cellular Response To Stress Sperm DNA Condensation Aggrephagy Cellular Response To Glucose Starvation Positive Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Glucose Stimulus Cellular Response To Estradiol Stimulus Cellular Senescence Membraneless Organelle Assembly DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Acetylation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Centrosome Cycle Cell Adhesion Cell Projection Organization Regulation Of Rac Protein Signal Transduction Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Regulation Of Cell Motility
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Cardiogenesis
Drugs		Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		197 interacting genes: AGO2 ALOX12 ALX1 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 AXIN1 BACH2 BARD1 BCL3 BLZF1 BMI1 BRCA1 C1orf174 CAVIN1 CBX8 CCDC106 CCDC125 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CEP70 COXFA4L2 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DMRTB1 DNAAF6 DUSP23 E2F1 E2F4 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B FAM161A FCHO1 FSAF1 GADD45G GAPDH GEMIN7 GET4 GIGYF1 GKAP1 GMCL1 GMCL2 GOLGA2 GSTO1 GTF2E2 GTSE1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4C1 H4C14 H4C16 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 HOOK1 HSF2BP ID3 IFT20 IK IKZF3 IL9R KCTD7 KDM2B KIF24 KLF4 KPNA3 KPNA4 KPNA5 KPNA6 KRT40 KRTAP10-3 KRTAP10-9 LARP4 LMNA LONRF1 LRIF1 LRP1 LZTS1 LZTS2 MAD2L1BP MAPRE1 MCC MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PCM1 PDCD5 PFKP PHC2 PICK1 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PPP1R16A PRDM6 PTPN4 PTPRS RB1 RBPMS RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SCRN2 SERTAD2 SHISA6 SNAPIN SNRPD2 SOX5 SPATA2 SQSTM1 SRF SRSF2 SSX2IP STAT3 STMN3 STX11 SYCE1 SYN1 TAX1BP1 TBX5 TELO2 TFIP11 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UBASH3B UHRF1 UPRT YJU2 YWHAG ZBTB1 ZBTB14 ZBTB2 ZBTB8A ZC2HC1C ZEB1 ZNF24 ZNF417 ZNF511 ZNF513 ZNF526 ZNF692 ZSCAN4	114 interacting genes: ABLIM3 ACTN1 ACTN2 AEN AFDN AP1M1 ARNT2 ATOSA BCL6 BEX2 BKGD BRCA1 BYSL CARD9 CCDC187 CCDC198 CCHCR1 CCNH CDC23 CDC42 CDCA7L CHCHD3 DAXX DRG1 DVL2 EAF2 EHHADH EIF4A2 ERAL1 FAM124B FAM161A FANCG FANCL FBF1 FNDC11 FRMD6 GEM GOLGA2 GOLGA8F GRAP2 HDAC4 HNRNPLL IKBKG INO80B KAT5 KDM1A KIF9 KIFC3 KLHL42 KRT15 KRT31 KRT40 KRTAP10-7 LATS1 LMO2 MCM7 MFAP1 MORN4 MOS MRPL53 NAA10 NDN NIF3L1 NOL12 NTAQ1 PHC2 PIMREG PKN1 PNMA1 POLL PRKAA1 PRKAB2 PRMT6 PRPF3 PRPF31 PSMA1 RAB1A RNF6 SCNM1 SHFL SSX2 SSX3 SYT17 TBP TEAD4 TFIP11 TOP3B TRIM42 TRIM54 TSGA10IP TSTD2 TTC23 WDR5 XIAP YWHAQ YWHAZ ZBTB24 ZFYVE26 ZGPAT ZMAT2 ZNF124 ZNF202 ZNF250 ZNF3 ZNF408 ZNF417 ZNF438 ZNF587 ZNF648 ZNF688 ZNF71 ZNF792 ZRSR2 ZSCAN12
Entrez ID		10524	117178
HPRD ID		03245	10566
Ensembl ID		ENSG00000172977	ENSG00000117155
Uniprot IDs		Q92993	B7ZB07 Q9Y2D8
PDB IDs		2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Metabolic Process DNA Binding Identical Protein Binding Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Transcription By RNA Polymerase II Chromatin Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process	Nucleus Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nuclear Androgen Receptor Binding Metal Ion Binding Regulation Of Metabolic Process DNA Damage Response DNA Recombination DNA-binding Transcription Factor Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Spliceosomal Complex Mitotic Spindle U2-type Precatalytic Spliceosome Keratin Filament MRNA Splicing, Via Spliceosome DNA Binding RNA Splicing, Via Transesterification Reactions Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleic Acid Metabolic Process AMP-activated Protein Kinase Activity Transcription Coactivator Activity Protein K6-linked Ubiquitination
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