KAT5 and TRIB3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		KAT5	TRIB3
Description		lysine acetyltransferase 5	tribbles pseudokinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Chromatin Nucleosome Swr1 Complex Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol Cytoskeleton Nuclear Lumen Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Mitotic Spindle Pole	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H2A Acetyltransferase Activity Histone H2AK5 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptide Crotonyltransferase Activity Peptide Butyryltransferase Activity DNA-binding Transcription Factor Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Immune System Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Apoptotic Process DNA Damage Response Spermatid Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Triglyceride Biosynthetic Process Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Neural Tube Development Neurogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Interleukin-2 Production Cellular Response To Stress Sperm DNA Condensation Aggrephagy Cellular Response To Glucose Starvation Positive Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Glucose Stimulus Cellular Response To Estradiol Stimulus Cellular Senescence Membraneless Organelle Assembly DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Acetylation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Autophagy Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Cardiogenesis	PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		197 interacting genes: AGO2 ALOX12 ALX1 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 AXIN1 BACH2 BARD1 BCL3 BLZF1 BMI1 BRCA1 C1orf174 CAVIN1 CBX8 CCDC106 CCDC125 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CEP70 COXFA4L2 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DMRTB1 DNAAF6 DUSP23 E2F1 E2F4 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B FAM161A FCHO1 FSAF1 GADD45G GAPDH GEMIN7 GET4 GIGYF1 GKAP1 GMCL1 GMCL2 GOLGA2 GSTO1 GTF2E2 GTSE1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4C1 H4C14 H4C16 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 HOOK1 HSF2BP ID3 IFT20 IK IKZF3 IL9R KCTD7 KDM2B KIF24 KLF4 KPNA3 KPNA4 KPNA5 KPNA6 KRT40 KRTAP10-3 KRTAP10-9 LARP4 LMNA LONRF1 LRIF1 LRP1 LZTS1 LZTS2 MAD2L1BP MAPRE1 MCC MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PCM1 PDCD5 PFKP PHC2 PICK1 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PPP1R16A PRDM6 PTPN4 PTPRS RB1 RBPMS RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SCRN2 SERTAD2 SHISA6 SNAPIN SNRPD2 SOX5 SPATA2 SQSTM1 SRF SRSF2 SSX2IP STAT3 STMN3 STX11 SYCE1 SYN1 TAX1BP1 TBX5 TELO2 TFIP11 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UBASH3B UHRF1 UPRT YJU2 YWHAG ZBTB1 ZBTB14 ZBTB2 ZBTB8A ZC2HC1C ZEB1 ZNF24 ZNF417 ZNF511 ZNF513 ZNF526 ZNF692 ZSCAN4	100 interacting genes: ACACA AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MDM2 MISP MYC OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PRKAB2 PRMT5 PRR19 PSMA3 RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SAXO4 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587
Entrez ID		10524	57761
HPRD ID		03245	09836
Ensembl ID		ENSG00000172977	ENSG00000101255
Uniprot IDs		Q92993	B4DMM9 J3KR25 Q96RU7
PDB IDs		2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Metabolic Process DNA Binding Identical Protein Binding Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Transcription By RNA Polymerase II Chromatin Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process	Nucleus Protein Binding Negative Regulation Of Gene Expression DNA-binding Transcription Factor Binding Identical Protein Binding Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gene Expression Axonemal A Tubule Inner Sheath Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasm Innate Immune Response PERK-mediated Unfolded Protein Response CHOP-ATF4 Complex Axonemal Microtubule DNA Deamination Chromatin RNA Metabolic Process Response To Radiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Signal Transduction By P53 Class Mediator Lewy Body Core Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Response To Light Stimulus Defense Response To Symbiont Regulation Of Fatty Acid Beta-oxidation Response To Interleukin-1 Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Translational Initiation
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