KAT5 and MDFI

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KAT5	MDFI
Description		lysine acetyltransferase 5	MyoD family inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Chromatin Nucleosome Swr1 Complex Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Cytosol Cytoskeleton Nuclear Lumen Piccolo Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Mitotic Spindle Pole	Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Histone H2A Acetyltransferase Activity Histone H2AK5 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptide Crotonyltransferase Activity Peptide Butyryltransferase Activity DNA-binding Transcription Factor Binding	Protein Binding Identical Protein Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Immune System Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Apoptotic Process DNA Damage Response Spermatid Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Triglyceride Biosynthetic Process Peptidyl-lysine Acetylation Triglyceride Biosynthetic Process Neural Tube Development Neurogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Interleukin-2 Production Cellular Response To Stress Sperm DNA Condensation Aggrephagy Cellular Response To Glucose Starvation Positive Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Glucose Stimulus Cellular Response To Estradiol Stimulus Cellular Senescence Membraneless Organelle Assembly DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Protein Acetylation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Aggrephagy Lipid Droplet Disassembly Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Maintenance Of Protein Location In Cell Negative Regulation Of DNA-templated Transcription Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Cardiogenesis
Drugs		Coenzyme A S-Acetyl-Cysteine
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 32203549) Heel bone mineral density ( 30598549) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Grapefruit juice consumption ( 31046077) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		197 interacting genes: AGO2 ALOX12 ALX1 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 AXIN1 BACH2 BARD1 BCL3 BLZF1 BMI1 BRCA1 C1orf174 CAVIN1 CBX8 CCDC106 CCDC125 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CEP70 COXFA4L2 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DMRTB1 DNAAF6 DUSP23 E2F1 E2F4 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B FAM161A FCHO1 FSAF1 GADD45G GAPDH GEMIN7 GET4 GIGYF1 GKAP1 GMCL1 GMCL2 GOLGA2 GSTO1 GTF2E2 GTSE1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4C1 H4C14 H4C16 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 HOOK1 HSF2BP ID3 IFT20 IK IKZF3 IL9R KCTD7 KDM2B KIF24 KLF4 KPNA3 KPNA4 KPNA5 KPNA6 KRT40 KRTAP10-3 KRTAP10-9 LARP4 LMNA LONRF1 LRIF1 LRP1 LZTS1 LZTS2 MAD2L1BP MAPRE1 MCC MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PCM1 PDCD5 PFKP PHC2 PICK1 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PPP1R16A PRDM6 PTPN4 PTPRS RB1 RBPMS RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SCRN2 SERTAD2 SHISA6 SNAPIN SNRPD2 SOX5 SPATA2 SQSTM1 SRF SRSF2 SSX2IP STAT3 STMN3 STX11 SYCE1 SYN1 TAX1BP1 TBX5 TELO2 TFIP11 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UBASH3B UHRF1 UPRT YJU2 YWHAG ZBTB1 ZBTB14 ZBTB2 ZBTB8A ZC2HC1C ZEB1 ZNF24 ZNF417 ZNF511 ZNF513 ZNF526 ZNF692 ZSCAN4	405 interacting genes: AANAT AASDHPPT ABCF3 ABHD11 ABHD17A ADAMTSL3 ADRA2C AEBP2 AGXT AKAP17A ANKRD13C-DT AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ARMC7 ATG12 ATN1 ATOSB ATP5F1D ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAG3 BAHD1 BANP BBS2 BCAM BCL6 BCL6B BEX1 BEX2 BEX3 C10orf62 C1orf216 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBLL2 CBX2 CBX8 CC2D1B CCDC116 CCDC120 CCDC185 CCDC187 CCDC198 CCDC33 CCER1 CCNL2 CDC20B CDC37 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHP2 CHRNG CIMAP1B CLPB CNNM3 CRACR2A CREB5 CRH CRX CRY1 CSNK1G2-AS1 CSNK1G3 CTRC CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNAJB13 DNMT3A DNPEP DOCK2 DOK3 DUSP6 DYNLT4 EBI3 EFEMP2 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FADS6 FAM120AOS FAM124B FAM161A FAM161B FAM27E3 FAM90A1 FARS2 FASTK FBXL18 FBXO34 FBXW5 FES FEZF1 FNDC11 FOXD4 FOXD4L1 FOXD4L3 FOXD4L6 FZD9 GABRD GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNE GNG5 GPANK1 GPATCH2L GPRIN2 GREM1 GTF3C5 HAPLN2 HASPIN HEYL HHEX HNRNPLL HOXA1 HOXB9 HPCAL1 HTR1B HYPK IFRD2 ILF3 INTS11 IQUB ITGB4 JOSD1 KANSL1 KAT5 KCTD7 KIAA0040 KIAA0408 KIF1A KLHL38 KPNA2 KRAS KRT77 LAMB3 LASP1 LCE1A LCE1B LCE1D LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LIMS2 LIN7A LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGEC3 MAGED1 MAGEF1 MAPK1 MAPKBP1 MBD1 MBD3L2 MCM5 MEOX2 METTL17 MGAT5B MRPL20-AS1 MVP MXI1 MYF5 MYOD1 MYOG MYPOP NAB2 NDUFA7 NECTIN2 NEU4 NIBAN3 NKD1 NOL4L-DT NPDC1 NPEPL1 NR1H2 NR1H3 NSD1 NTAQ1 NUBP2 NUFIP2 ODAD4 ODAPH ODF1 OLIG3 OTX1 PARP11 PATZ1 PBXIP1 PCSK5 PDGFA PDGFB PDIA5 PDS5A PELI2 PGLS PHF1 PHLDA1 PIBF1 PID1 PIDD1 PIH1D2 PIN1 PKD2 PLEKHG4 POLL POM121L8P PRKAB2 PRPF18 PRPF31 PRR34 PTK7 PTPMT1 RABL6 RAC1 RASD1 REG3A REX1BD RFX2 RHOXF2 RIN1 RIPPLY1 RNF111 RNF6 RTP5 SAPCD2 SCAMP4 SCNM1 SELENOM SEMA3B SERF2 SFI1 SHFL SHMT1 SIX1 SLC13A5 SLC15A3 SLC25A10 SLC33A2 SLC35A2 SLC35D4 SLC9A1 SMYD1 SNX18 SOCS7 SPATA24 SPATA3 SPATA8 SPG7 SPMAP2 SPMIP2 SPON1 SPRED2 SPRY1 SPRY2 SUOX TACO1 TAP1 TASOR2 TBC1D3B TBC1D3G TCEANC TCF3 TEAD4 TEDC2 TGIF1 TH THAP7 TIE1 TINAGL1 TLE5 TMIE TNNI1 TNP2 TOR1A TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TSFM TSGA10IP TSPAN4 TSPYL1 TSPYL6 TTC23 TTLL10 TUSC2 TXN2 TYMSOS TYRO3 USP20 USP6 VASN VGLL3 VHL VPS72 VSTM4 WDFY3 WNT11 YPEL3 YY1 ZBBX ZBTB24 ZBTB25 ZBTB42 ZBTB9 ZC3HAV1 ZDHHC1 ZFYVE26 ZIM2 ZNF101 ZNF12 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF221 ZNF223 ZNF23 ZNF230 ZNF264 ZNF266 ZNF330 ZNF408 ZNF414 ZNF417 ZNF426 ZNF433 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF461 ZNF479 ZNF490 ZNF491 ZNF497 ZNF512B ZNF524 ZNF559 ZNF564 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF607 ZNF613 ZNF646 ZNF648 ZNF662 ZNF669 ZNF670 ZNF679 ZNF688 ZNF696 ZNF707 ZNF764 ZNF784 ZNF785 ZNF786 ZNF79 ZNF837 ZNF844 ZNHIT1
Entrez ID		10524	4188
HPRD ID		03245	07280
Ensembl ID		ENSG00000172977	ENSG00000112559
Uniprot IDs		Q92993	B1AKB6 Q99750
PDB IDs		2EKO 2OU2 4QQG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Metabolic Process DNA Binding Identical Protein Binding Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Localization To Organelle Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Gene Expression Transcription By RNA Polymerase II Chromatin Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex Chromatin Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process	Protein Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Metal Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratinization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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