TSHR and MOG

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		TSHR	MOG
Name		thyroid stimulating hormone receptor	myelin oligodendrocyte glycoprotein
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Regulation Of Cytokine Production Cell Adhesion Central Nervous System Development Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	None
Drugs		Thyrotropin alfa	None
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	None
GWAS		Graves' disease ( 21841780 22922229 ) Hair morphology ( 19896111 ) Male sexual orientation ( 29217827 ) Maximal oxygen uptake response ( 25729143 ) Obstetric antiphospholipid syndrome ( 28424481 ) Optic nerve measurement (rim area) ( 20395239 ) Smooth-surface caries ( 24556642 ) Thyroid stimulating hormone levels ( 30367059 32769997 ) Tourette syndrome ( 30818990 ) Uric acid levels ( 21294900 ) Urinary albumin excretion ( 32277301 ) Visceral fat ( 22589738 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 22412388 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Platelet count ( 26805783 ) Pulmonary function (smoking interaction) ( 23284291 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	4 interacting genes: ADRB2 PRNP STRIT1 TSHR
Entrez ID		7253	4340
HPRD ID		04537	11831
Ensembl ID		ENSG00000165409	ENSG00000204655
Uniprot IDs		P16473	Q16653 Q5SSB8
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	Not available
GO Terms Enriched among Interactors		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Protein-containing Complex Binding Cellular Response To Amyloid-beta Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Response To Amyloid-beta Amyloid-beta Binding Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis Type 8 Metabotropic Glutamate Receptor Binding Cellular Response To Thyrotropin-releasing Hormone Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cold-induced Thermogenesis Cellular Response To Oxygen-containing Compound Beta2-adrenergic Receptor Activity Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of Multicellular Organismal Process Receptor Complex Norepinephrine Binding Type 5 Metabotropic Glutamate Receptor Binding Cellular Response To Glycoprotein Response To Psychosocial Stress Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dendritic Spine Maintenance Cupric Ion Binding Regulation Of Muscle System Process Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Signaling Receptor Activity Positive Regulation Of Autophagosome Maturation Heat Generation ATP-dependent Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Adrenergic Receptor Activity Cuprous Ion Binding Diet Induced Thermogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Protein-hormone Receptor Activity Dendritic Spine Maintenance