TSHR and SLC9D1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TSHR	SLC9D1
Description		thyroid stimulating hormone receptor	solute carrier family 9 member D1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Membrane
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Antiporter Activity Potassium:proton Antiporter Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Monoatomic Ion Transport Monoatomic Cation Transport Transmembrane Transport Potassium Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	4 interacting genes: EGFR GLP1R HSPB1 TSHR
Entrez ID		7253	55002
HPRD ID		04537	12612
Ensembl ID		ENSG00000165409	ENSG00000150403
Uniprot IDs		P16473	A0A024RE09 Q6UWJ1
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Regulation Of Protein Kinase C Signaling G Protein-coupled Peptide Receptor Activity Cell Surface Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Protein Kinase C Signaling Cellular Response To Thyrotropin-releasing Hormone Shc-EGFR Complex Cellular Response To Oxygen-containing Compound Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Cellular Response To Peptide Hormone Stimulus Glucagon Receptor Activity Protein Kinase C Inhibitor Activity Receptor Complex Regulation Of Multicellular Organismal Process Epidermal Growth Factor Binding Cellular Response To Glycoprotein Transmembrane Signaling Receptor Activity Basolateral Plasma Membrane Response To Psychosocial Stress Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Learning Or Memory Cognition Establishment Of Protein Localization ERBB2-EGFR Signaling Pathway Response To Growth Factor Post-translational Protein Targeting To Membrane, Translocation Response To Peptide Hormone Signaling Receptor Activity Anterograde Axonal Protein Transport Salivary Gland Morphogenesis Cellular Response To Hormone Stimulus Protein-hormone Receptor Activity Cellular Localization Cellular Response To Glucagon Stimulus Response To UV-A Regulation Of Protein Phosphorylation Negative Regulation Of Cardiocyte Differentiation G Protein-coupled Receptor Activity Activation Of Adenylate Cyclase Activity Protein Transport Along Microtubule Contractile Muscle Fiber Eyelid Development In Camera-type Eye Positive Regulation Of Endothelial Cell Chemotaxis
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