TSHR and TSHB

Number of citations of the paper that reports this interaction (PubMedID 2558651)
0

Data Source:
HPRD (in vivo)

		TSHR	TSHB
Description		thyroid stimulating hormone receptor	thyroid stimulating hormone subunit beta
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Signaling Receptor Binding Hormone Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Anatomical Structure Morphogenesis
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	Glycoprotein hormones Thyroxine biosynthesis Hormone ligand-binding receptors G alpha (s) signalling events
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	California verbal learning test score ( 31596458)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB	2 interacting genes: CGA TSHR
Entrez ID		7253	7252
HPRD ID		04537	11766
Ensembl ID		ENSG00000165409	ENSG00000134200
Uniprot IDs		P16473	P01222
PDB IDs		2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7	7T9I 7UTZ 7XW5
Enriched GO Terms of Interacting Partners?		G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure	Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Hormone-mediated Signaling Pathway Follicle-stimulating Hormone Complex Cellular Response To Thyrotropin-releasing Hormone Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Pituitary Gonadotropin Complex Follicle-stimulating Hormone Signaling Pathway Cellular Response To Hormone Stimulus Luteinizing Hormone Secretion Cellular Response To Glycoprotein Gonadotropin Secretion Protein-hormone Receptor Activity Response To Hormone Thyroid Hormone Generation G Protein-coupled Receptor Signaling Pathway Thyroid Hormone Metabolic Process Positive Regulation Of Cell Population Proliferation Thyroid Gland Development Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Organ Growth G Protein-coupled Peptide Receptor Activity Ovulation Cycle Process Positive Regulation Of Steroid Metabolic Process Organ Growth G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Steroid Biosynthetic Process Regulation Of Cell Population Proliferation Phenol-containing Compound Metabolic Process Hormone Secretion Golgi Lumen Hormone Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Organ Growth Negative Regulation Of Developmental Growth Regulation Of Steroid Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Hormone Activity
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